Vespid chemotactic peptide precursor from the wasp, Vespa magnifica (Smith)
文献类型：期刊论文
| 作者 | Yu HN1; Yang HL3,4; Ma DY3,4; Lv Y2; Liu TG2; Zhang KY2; Lai R2,3; Liu JZ[*]1 |
| 刊名 | TOXICON
 |
| 出版日期 | 2007 |
| 卷号 | 50期号:3页码:377-382 |
| 关键词 | wasp amphibian Vespid chemotactic peptide (VCP) antimicrobial peptides (AMPs) biosynthesis |
| ISSN号 | 0041-0101 |
| 通讯作者 | rlai@mail.kiz.ac.cn ; liujingze@mail.hebtu.edu.cn |
| 合作状况 | 其它 |
| 英文摘要 | Despite the evolutional distance between wasp and amphibian, vespid chemotactic peptide (VCP), an important component of wasp venom, are found sharing remarkable similarities with the temporin antimicrobial peptides (AMPs) from Ranid frog, Amolops loloensis. Not only their amino acid sequences are highly similar, but they are both microbe-killing and can induce the cellular chemotactic response. However, whether the two peptides possess identical biosynthesis pathway was still not clear due to the unsolved gene sequence of VCP putative precursor. In this paper, a cDNA encoding one of VCP precursors was cloned from the venom sac cDNA library of the wasp, Vespa magnfica (Smith), and the corresponding native VCP was purified from the venoms. It was shown that the VCP precursor highly resembled terriporin precursor not only in the sequence size but also in the sequences of their corresponding mature peptides. However, the enzyme-cutting sites and the possible processing enzymes for both peptides were different, which for VCP were dipeptidyl peptidase IV and trypsin-like proteases, while for temporin were only trypsin-like protease. The current results suggested that the biosynthesis mode of VCP was different from that of temporin AMP, even though the two mature peptides were similar in many ways. It is also the first report about VCP precursor from wasp venom (C) 2007 Published by Elsevier Ltd. |
| 收录类别 | SCI |
| 资助信息 | This work was supported by the Chinese National Natural Science Foundation (30570360, 30670456), Yunnan Natural Science Foundation (2005C0054M, 2006C0011Z) and Jiangsu Natural Science Founda- tion (BK2005422). |
| 原文出处 | 200750377.pdf |
| 语种 | 英语 |
| 公开日期 | 2010-08-24 |
| 源URL | [http://159.226.149.42:8088/handle/152453/2507]  |
| 专题 | 昆明动物研究所_动物毒素室 昆明动物研究所_动物模型与人类重大疾病机理重点实验室 |
| 作者单位 | 1.College of Life Sciences School of Hebei Normal University, Shijiazhuang, Hebei, 050016, China 2.Key Laboratory of Microbiological Engineering of Agricultural Environment, Ministry of Agriculture, Life Sciences College of Nanjing Agricultural University, Nanjing, Jiangsu 210095, China 3.Biotoxin Units of Key Laboratory of Animal Models and Human Disease Mechanisms, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, Yunnan, China 4.Graduate School of the Chinese Academy of Sciences, Beijing 100009, China |
| 推荐引用方式 GB/T 7714 | Yu HN,Yang HL,Ma DY,et al. Vespid chemotactic peptide precursor from the wasp, Vespa magnifica (Smith)[J]. TOXICON,2007,50(3):377-382. |
| APA | Yu HN.,Yang HL.,Ma DY.,Lv Y.,Liu TG.,...&Liu JZ[*].(2007).Vespid chemotactic peptide precursor from the wasp, Vespa magnifica (Smith).TOXICON,50(3),377-382. |
| MLA | Yu HN,et al."Vespid chemotactic peptide precursor from the wasp, Vespa magnifica (Smith)".TOXICON 50.3(2007):377-382. |
入库方式： OAI收割
来源：昆明动物研究所
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