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A bactericidal homodimeric phospholipases A(2) from Bungarus fasciatus venom

文献类型：期刊论文

作者Xu CH1; Ma DY2,4; Yu HN3; Li ZJ1; Liang JG1; Lin GQ1; Zhang Y2; Lai R[*]1,2
刊名PEPTIDES
出版日期2007
卷号28期号:5页码:969-973
关键词PLA(2) Bungarus fasciatus antibacterial snake venom
ISSN号0196-9781
通讯作者rlai72@njau.edu.cn
合作状况其它
英文摘要Group IIA secretory phospholipases A(2) (sPLA(2)-II) is generally known to display potent grampositive bactericidal activity, while group IA sPLA(2) (sPLA(2)-I) reportedly is not. In this work, a novel sPLA(2)-I named BFPA was identified from Bungarus fasciatus venom, and its antimicrobial activity was studied as well. The amino acid sequence of the venomous protein precursor was 145-amino acid in length, and contained a predicted 27-amino acid signal peptide and a 118-amino acid mature protein. Unlike the well-known sPLA(2)-IS, which have 14 half-cysteines forming 7 intramolecular disulfide bridges, BFPA possesses 15 half-cysteines. The additional cysteine might contribute to the formation of an intermolecular disulfide bridge of the homodimeric protein. In the biological activities assays, BFPA displayed the activities of anticoagulation and bactericidal against Escherichia coli and Staphylococcus aureus. This study is the first report about gram-positive bactericidal activity of sPLA(2)-I.
收录类别SCI
资助信息This work was supported by the Chinese National Natural Science Foundation (30570360, 30670456), Yunnan Natural Science Foundation (2005C0054M, 2006C0011Z), the grant 2006BAD06B07 from the Ministry of Science and Technology of the People’s Republic of China, and Jiangsu Natural Science Foundation (BK2005422).
原文出处200728969.pdf
语种英语
公开日期2010-08-24
源URL[http://159.226.149.42:8088/handle/152453/2511]  
专题昆明动物研究所_动物毒素室
昆明动物研究所_动物模型与人类重大疾病机理重点实验室
昆明动物研究所_动物活性蛋白多肽组学
作者单位1.Key Laboratory of Microbiological Engineering of Agricultural Environment, Ministry of Agriculture, Life Sciences College of Nanjing Agricultural University, Nanjing 210095, Jiangsu, China
2.Biotoxin Units of Key Laboratory of Animal Models and Human Disease Mechanisms, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, Yunnan, China
3.College of Life Sciences, School of Hebei Normal University, Shijiazhuang 050016, Hebei, China
4.Graduate School of the Chinese Academy of Sciences, Beijing 100009, China
推荐引用方式
GB/T 7714		 Xu CH,Ma DY,Yu HN,et al. A bactericidal homodimeric phospholipases A(2) from Bungarus fasciatus venom[J]. PEPTIDES,2007,28(5):969-973.
APA Xu CH.,Ma DY.,Yu HN.,Li ZJ.,Liang JG.,...&Lai R[*].(2007).A bactericidal homodimeric phospholipases A(2) from Bungarus fasciatus venom.PEPTIDES,28(5),969-973.
MLA Xu CH,et al."A bactericidal homodimeric phospholipases A(2) from Bungarus fasciatus venom".PEPTIDES 28.5(2007):969-973.

入库方式： OAI收割

来源：昆明动物研究所

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