A small trypsin inhibitor from the frog of Odorrana grahami
文献类型：期刊论文
| 作者 | Li JX1,4; Wu J1,4; Wang YP2,4; Xu XQ2,4; Liu TG1; Lai R[*]1,2; Zhu HJ[*]3 |
| 刊名 | BIOCHIMIE
 |
| 出版日期 | 2008 |
| 卷号 | 90期号:9页码:1356-1361 |
| 关键词 | serine protease inhibitor amphibian Odorrana grahami |
| ISSN号 | 0300-9084 |
| 通讯作者 | rlai@mail.kiz.ac.cn ; hjzhu@mail.kib.ac.cn |
| 合作状况 | 其它 |
| 英文摘要 | A novel peptide inhibitor (OGTI) of serine protease with a molecular weight of 1949.8, was purified from the skin secretion of the frog, Odorrana grahami. Of the tested serine proteases, OGTI only inhibited the hydrolysis activity of trypsin on synthetic chromogenic substrate. This precursor deduced from the cDNA sequence is composed of 70 amino acid residues. The mature OGTI contains 17 amino acid residues including a six-residue loop disulfided by two half-cysteines (AVNIPFKVHFRCKAAFC). In addition to its unique six-residue loop, the overall structure and precursor of OGTI are different from those of other serine protease inhibitors. It is also one of the smallest serine protease inhibitors ever found. |
| 收录类别 | SCI |
| 资助信息 | This work was supported by Yunnan Natural Science Foun- dation (2006C0011Z), KSCX2-YW-R-20 and KSCX2-YW-G- 024 from Chinese Academy of Sciences. C.U. Pittman Jr. from Mississippi State University, USA assisted with the writing. |
| 原文出处 | 2008901356.pdf |
| 语种 | 英语 |
| 公开日期 | 2010-08-24 |
| 源URL | [http://159.226.149.42:8088/handle/152453/2523]  |
| 专题 | 昆明动物研究所_动物毒素室 昆明动物研究所_动物模型与人类重大疾病机理重点实验室 |
| 作者单位 | 1.Tiotoxin Units of Key Laboratory of Animal Models and Human Disease Mechanisms, Kunming Institute of Zoology, Chinese Academy of Sciences (CAS), Kunming 650223, Yunnan, China 2.Key Laboratory of Microbiological Engineering of Agricultural Environment, Ministry of Agriculture, Life Sciences College of Nanjing Agricultural University, Nanjing 210095, Jiangsu, China 3.State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, CAS, Kunming 650224, China 4.Graduate School of the Chinese Academy of Sciences, Beijing 100009, China |
| 推荐引用方式 GB/T 7714 | Li JX,Wu J,Wang YP,et al. A small trypsin inhibitor from the frog of Odorrana grahami[J]. BIOCHIMIE,2008,90(9):1356-1361. |
| APA | Li JX.,Wu J.,Wang YP.,Xu XQ.,Liu TG.,...&Zhu HJ[*].(2008).A small trypsin inhibitor from the frog of Odorrana grahami.BIOCHIMIE,90(9),1356-1361. |
| MLA | Li JX,et al."A small trypsin inhibitor from the frog of Odorrana grahami".BIOCHIMIE 90.9(2008):1356-1361. |
入库方式： OAI收割
来源：昆明动物研究所
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