An immunoregulatory peptide from salivary glands of the horsefly, Hybomitra atriperoides
文献类型：期刊论文
| 作者 | Yan XW1,2; Feng H2; Yu HN1; Yang XL1; Liu JZ[*]1; Lai R[*]2,3 |
| 刊名 | DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
 |
| 出版日期 | 2008 |
| 卷号 | 32期号:10页码:1242-1247 |
| 关键词 | horsefly blood-feeding cytokine immunosuppression ectoparasite-host relationship |
| ISSN号 | 0145-305X |
| 通讯作者 | jzliu21@heinfo.net ; rltai72@njau.edu.cn |
| 合作状况 | 其它 |
| 英文摘要 | Horseflies are economically important blood-feeding arthropods and also a nuisance for humans, and vectors for filariasis. They rely heavily on the pharmacological propriety of their saliva to get blood meat and suppress immune reactions of hosts. Little information is available on horsefly immune suppressants. By high-performance liquid chromatography (HPLC) purification coupling with pharmacological testing, an immunoregulatory peptide named immunoregulin HA has been identified and characterized from salivary glands of the horsefly of Hybomitra atriperoides (Diptera, Tabanidae). Immunoregulin HA could inhibit the secretion of interferon-gamma (IFN-gamma) and monocyte chemoattractant protein (MCP-1) and increase the secretion of interteukin-10 (IL-10) induced by lipopolysaccharide (LIPS) in rat splenocytes. IL-10 is a suppressor cytokine of T-cell proliferative and cytokine responses. IL-10 can inhibit the elaboration of pro-inflammatory cytokines. Immunoregulin HA possibly unregulated the IL-10 production to inhibit IFN-gamma and MCP-1 secretion in the current experiments. This immunosuppression may facilitate the blood feeding of this horsefly. The current works will facilitate to understand the molecular mechanisms of the ectoparasite-host relationship. |
| 收录类别 | SCI |
| 资助信息 | This project was supported by the National Natural Science Foundation of China (30670259), Natural Science Foundation of Hebei province (C2007000266), and the Ministry of Science and Technology of the People’s Republic of China (2007AA02Z192). |
| 原文出处 | 2008321242.pdf |
| 语种 | 英语 |
| 公开日期 | 2010-08-24 |
| 源URL | [http://159.226.149.42:8088/handle/152453/2527]  |
| 专题 | 昆明动物研究所_动物毒素室 昆明动物研究所_动物模型与人类重大疾病机理重点实验室 |
| 作者单位 | 1.College of Life Sciences School of Heibei Normal University, Shijiazhuang, Hebei 050016, China 2.Key Laboratory of Microbiological Engineering of Agricultural Environment, Ministry of Agriculture, Life Sciences College of Nanjing Agricultural University, Nanjing, Jiangsu 210095, China 3.Biotoxin Units of Key Laboratory of Animal Models and Human Disease Mechanisms, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, Yunnan, China |
| 推荐引用方式 GB/T 7714 | Yan XW,Feng H,Yu HN,et al. An immunoregulatory peptide from salivary glands of the horsefly, Hybomitra atriperoides[J]. DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY,2008,32(10):1242-1247. |
| APA | Yan XW,Feng H,Yu HN,Yang XL,Liu JZ[*],&Lai R[*].(2008).An immunoregulatory peptide from salivary glands of the horsefly, Hybomitra atriperoides.DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY,32(10),1242-1247. |
| MLA | Yan XW,et al."An immunoregulatory peptide from salivary glands of the horsefly, Hybomitra atriperoides".DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY 32.10(2008):1242-1247. |
入库方式： OAI收割
来源：昆明动物研究所
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