An anticoagulant serine protease from the wasp venom of Vespa magnifica
文献类型：期刊论文
| 作者 | Han JY1,3; You DW1,4; Xu XQ1,4; Han W3; Lu Y2; Lai R[*]1,2; Meng QX[*]1 |
| 刊名 | TOXICON
 |
| 出版日期 | 2008 |
| 卷号 | 51期号:5页码:914-922 |
| 关键词 | wasp venom Vespa magnifica serine protease blood coagulation anticoagulant |
| ISSN号 | 0041-0101 |
| 通讯作者 | rlai@mail.kiz.ac.cn ; qxmene@sina.com |
| 合作状况 | 其它 |
| 英文摘要 | Wasp is an important venomous animal that can induce human fatalities. Coagulopathy is a clinical symptom after massive wasp stings, but the reason leading to the envenomation manifestation is still not known. In this paper, a toxin protein is purified and characterized by Sephadex G-75 gel filtration, CM-Sephadex C-25 cationic exchange and fast protein liquid chromatography (FPLC) from the venom of the wasp, Vespa magnifica (Smith). This protein, named magnvesin. contains serine protease-like activity and inhibits blood coagulation. The cDNA encoding magnvesin is cloned from the venom sac cDNA library of the wasp. The deduced protein from the cDNA is composed of 305 amino acid residues. Magnvesin shares 52% identity with allergen serine protease from the wasp Polistes dominulus. Magnvesin exerted its anti-coagulant function by hydrolyzing coagulant factors TF, VII, VIII, IX and X. |
| 收录类别 | SCI |
| 资助信息 | This work was supported by the Chinese National Natural Science Foundation (30570360, 30670456) and Chinese Academy of Sciences (KSCXZ-YW-R- 088). |
| 原文出处 | 200851914.pdf |
| 语种 | 英语 |
| 公开日期 | 2010-08-24 |
| 源URL | [http://159.226.149.42:8088/handle/152453/2541]  |
| 专题 | 昆明动物研究所_动物毒素室 昆明动物研究所_动物模型与人类重大疾病机理重点实验室 |
| 作者单位 | 1.Biotoxin Units of Key Laboratories of Animal Models and Human Disease Mechanisms, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, Yunnan, China 2.Key Laboratory of Microbiological Engineering of Agricultural Environment, Ministry of Agriculture, Life Sciences College of Nanjing Agricultural University, Nanjing 210095, Jiangsu, China 3.College of Animal Science and Veterinary Medicine, Jilin University, Changchun 130062, Jilin, China 4.Graduate School of the Chinese Academy of Sciences, Beijing100009, China |
| 推荐引用方式 GB/T 7714 | Han JY,You DW,Xu XQ,et al. An anticoagulant serine protease from the wasp venom of Vespa magnifica[J]. TOXICON,2008,51(5):914-922. |
| APA | Han JY.,You DW.,Xu XQ.,Han W.,Lu Y.,...&Meng QX[*].(2008).An anticoagulant serine protease from the wasp venom of Vespa magnifica.TOXICON,51(5),914-922. |
| MLA | Han JY,et al."An anticoagulant serine protease from the wasp venom of Vespa magnifica".TOXICON 51.5(2008):914-922. |
入库方式： OAI收割
来源：昆明动物研究所
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