A novel antimicrobial peptide from amphibian skin secretions of Odorrana grahami
文献类型：期刊论文
| 作者 | Che QL1; Zhou Y1; Yang HL2; Li JX2,3; Xu XQ2,3; Lai R[*]1,2 |
| 刊名 | PEPTIDES
 |
| 出版日期 | 2008 |
| 卷号 | 29期号:4页码:529-535 |
| 关键词 | amphibian antimicrobial peptide Odorrana grahami innate immunity |
| ISSN号 | 0196-9781 |
| 通讯作者 | rlai72@njau.edu.cn |
| 合作状况 | 其它 |
| 英文摘要 | A novel antimicrobial peptide named odorranain-NR was identified from skin secretions of the diskless odorous frog, Odorrana grahami. It is composed of 23 amino acids with an amino acid sequence of GLLSGILGAGKHIVCGLTGCAKA. Odorranain-NR was classified into a novel family of antimicrobial peptide although it shared similarity with amphibian antimicrobial peptide family of nigrocin. Odorranain-NR has an unusual intramolecular disulfide-bridged hexapeptide segment that is different from the intramolecular disulfide-bridged heptapeptide segment at the C-terminal end of nigrocins. Furthermore, the -AKA fragment at the C-terminal of odorranain-NR is also different from nigrocins. Three different cDNAs encoding two odorranain-NR precursors and only one mature odorranain-NR was cloned from the cDNA library of the skin of O. grahami. This peptide showed antimicrobial activities against tested microorganisms except Escherichia coli (ATCC25922). Its antimicrobial mechanisms were investigated by transmission electron microcopy. odorranain-NR exerted its antimicrobial functions by various means depending on different microorganisms. |
| 收录类别 | SCI |
| 资助信息 | This work was supported by Yunnan Natural Science Foundation (2006C0011Z), 2006BAD06B07 from the Ministry of Science and Technology of the People’s Republic of China. |
| 原文出处 | 200829529.pdf |
| 语种 | 英语 |
| 公开日期 | 2010-08-24 |
| 源URL | [http://159.226.149.42:8088/handle/152453/2543]  |
| 专题 | 昆明动物研究所_动物毒素室 昆明动物研究所_动物模型与人类重大疾病机理重点实验室 |
| 作者单位 | 1.Key Laboratory of Microbiological Engineering of Agricultural Environment, Ministry of Agriculture, Life Sciences College of Nanjing Agricultural University, Nanjing, Jiangsu 210095, China 2.Biotoxin Units of Key Laboratory of Animal Models and Human Disease Mechanisms, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, 650223 Yunnan, China 3.Graduate School of the Chinese Academy of Sciences, Beijing 100009, China |
| 推荐引用方式 GB/T 7714 | Che QL,Zhou Y,Yang HL,et al. A novel antimicrobial peptide from amphibian skin secretions of Odorrana grahami[J]. PEPTIDES,2008,29(4):529-535. |
| APA | Che QL,Zhou Y,Yang HL,Li JX,Xu XQ,&Lai R[*].(2008).A novel antimicrobial peptide from amphibian skin secretions of Odorrana grahami.PEPTIDES,29(4),529-535. |
| MLA | Che QL,et al."A novel antimicrobial peptide from amphibian skin secretions of Odorrana grahami".PEPTIDES 29.4(2008):529-535. |
入库方式： OAI收割
来源：昆明动物研究所
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