Cloning and characterization of the first amphibian bradykinin gene
文献类型：期刊论文
| 作者 | Chen MD1; Che QL1; Wang X1; Li JX2; Yang HL2,3; Li DS2; Zhang KY1; Lai R[*]1,2 |
| 刊名 | BIOCHIMIE
 |
| 出版日期 | 2010 |
| 卷号 | 92期号:3页码:226-231 |
| 关键词 | Amphibian Bradykinin Gene Skin |
| ISSN号 | 0300-9084 |
| 通讯作者 | rlai72@njau.edu.cn |
| 合作状况 | 其它 |
| 英文摘要 | More than ten bradykinin-related peptides and their cDNAs; have been identified from amphibians, but their genes are unknown. In present study, four cDNAs encoding one, two, four and six copies of bradykinin-related peptides were cloned from the frog (Odorrana grahami) skin cDNA library, respectively. Three bradykinin-related peptides (bradykinin, Thr6-bradykinin, Leu5Thr6-bradykinin) were deduced from these four cDNA sequences. Based on the cDNA sequence, the gene sequence encoding an amphibian bradykinin-related peptide from O. grahami was determined. It is composed of 7481 base pairs including two exons and two introns. The first exon codes signal peptide and the second exon codes acidic spacer peptide and Thr6-bradykinin. The promoter region of the bradykinin gene contains several putative recognition sites for nuclear factors, such as SRY, GATA-1, LYF-1, DeltaE, CDXA, NKX-2.5, MIF1 and S8. The current work may facilitate to understand the regulation and possible functions of amphibian skin bradykinin-related peptides. |
| 收录类别 | SCI |
| 资助信息 | This Study was supported by grants from the 973 program (2009CB941703, 2006CB504002), the Chinese Natural Science Funds (30630030), and the Program of Changiiang Scholars and Innovative Research Team in University (IRT0631). |
| 原文出处 | 201092226.pdf |
| 语种 | 英语 |
| 公开日期 | 2010-08-24 |
| 源URL | [http://159.226.149.42:8088/handle/152453/2577]  |
| 专题 | 昆明动物研究所_动物毒素室 昆明动物研究所_动物模型与人类重大疾病机理重点实验室 |
| 作者单位 | 1.Key Laboratory of Microbiological Engineering of Agricultural Environment, Ministry of Agriculture, Life Sciences College of Nanjing Agricultural University, Nanjing, Jiangsu 210095, China 2.Key Laboratory of Animal Models and Human Disease Mechanisms, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, Yunnan, China 3.Graduate School of the Chinese Academy of Sciences, Beijing100009, China |
| 推荐引用方式 GB/T 7714 | Chen MD,Che QL,Wang X,et al. Cloning and characterization of the first amphibian bradykinin gene[J]. BIOCHIMIE,2010,92(3):226-231. |
| APA | Chen MD.,Che QL.,Wang X.,Li JX.,Yang HL.,...&Lai R[*].(2010).Cloning and characterization of the first amphibian bradykinin gene.BIOCHIMIE,92(3),226-231. |
| MLA | Chen MD,et al."Cloning and characterization of the first amphibian bradykinin gene".BIOCHIMIE 92.3(2010):226-231. |
入库方式： OAI收割
来源：昆明动物研究所
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