Five novel antimicrobial peptides from skin secretions of the frog, Amolops loloensis
文献类型：期刊论文
| 作者 | Wang MJ1; Wang Y2,3; Song YZ2,3; Ma DY2,3; Yang HL2,3; Ma YF2,3; Lai R[*]1,2; Wang AL1 |
| 刊名 | Comparative Biochemistry and Physiology, Part B
 |
| 出版日期 | 2010 |
| 卷号 | 155期号:1页码:72-76 |
| 关键词 | Amphibian Antimicrobial peptides Skin Innate immunity Amolops loloensis |
| ISSN号 | 1096-4959 |
| 通讯作者 | rlai@mail.kiz.ac.cn |
| 合作状况 | 其它 |
| 英文摘要 | While investigating antimicrobial peptide diversity of Amolops loloensis, five novel antimicrobial peptides belonging to two families were identified from skin secretions of this frog. The first family including two members is esculentin-2-AL (esculentin-2-ALa and -ALb): the second family including three members is temporin-AL (temporin-ALd to -ALf). The family of esculentin-2-AL is composed of 37 amino acid residues (aa); the family of temporin-AL is composed of 16, 13 and 10 aa, respectively. All of these antimicrobial peptides showed antimicrobial activities against tested microorganisms. cDNAs encoding precursors of esculentin-2-ALs and temporin-ALs were cloned from the skin cDNA library of A. loloensis. All the precursors share similar overall structures. There is a typical prohormone processing signal (Lys-Arg) located between the acidic propiece and the mature peptide. The antimicrobial peptide family of esculentin-2 is firstly reported in the genus of Amolops. Combined with previous reports, a total of four antimicrobial peptide families have been identified from the genus of Amolops; three of them are also found in the genus of Rana. These results suggest the possible evolutionary connection between the genera Amolops and Rana |
| 收录类别 | SCI |
| 资助信息 | This work was supported by the Chinese National Natural Science Foundation (30830021), Chinese Academy of Sciences (KSCXZ-YW-R- 088, KSCX2-YW-G-024), and the Ministry of Science (2008AA02Z133, 2007AA100602). |
| 原文出处 | 2010155172.pdf |
| 语种 | 英语 |
| 公开日期 | 2010-08-24 |
| 源URL | [http://159.226.149.42:8088/handle/152453/2583]  |
| 专题 | 昆明动物研究所_动物毒素室 昆明动物研究所_动物模型与人类重大疾病机理重点实验室 |
| 作者单位 | 1.Key Laboratory of Microbiological Engineering of Agricultural Environment, Ministry of Agriculture, Life Sciences College of Nanjing Agricultural University, Nanjing, Jiangsu, 210095, China 2.Key Laboratory of Animal Models and Human Disease Mechanisms, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, Yunnan, China 3.Graduate School of the Chinese Academy of Sciences, Beijing 100009, China |
| 推荐引用方式 GB/T 7714 | Wang MJ,Wang Y,Song YZ,et al. Five novel antimicrobial peptides from skin secretions of the frog, Amolops loloensis[J]. Comparative Biochemistry and Physiology, Part B,2010,155(1):72-76. |
| APA | Wang MJ.,Wang Y.,Song YZ.,Ma DY.,Yang HL.,...&Wang AL.(2010).Five novel antimicrobial peptides from skin secretions of the frog, Amolops loloensis.Comparative Biochemistry and Physiology, Part B,155(1),72-76. |
| MLA | Wang MJ,et al."Five novel antimicrobial peptides from skin secretions of the frog, Amolops loloensis".Comparative Biochemistry and Physiology, Part B 155.1(2010):72-76. |
入库方式： OAI收割
来源：昆明动物研究所
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