Bombinakinin M gene associated peptide, a novel bioactive peptide from skin secretions of the toad Bombina maxima
文献类型：期刊论文
| 作者 | Lai R; Liu H; Lee WH; Zhang Y[*] |
| 刊名 | PEPTIDES
 |
| 出版日期 | 2003 |
| 卷号 | 24期号:2页码:199-204 |
| 关键词 | Amphibian Bombina maxima Peptide Food intake inhibition Bradykinin Bombinakinin-GAP |
| ISSN号 | 0196-9781 |
| 通讯作者 | zhangy@mail.kiz.ac.cn |
| 合作状况 | 其它 |
| 英文摘要 | A novel 28-amino acid peptide, termed bombinakinin-GAP, was purified and characterized from skin secretions of the toad Bombina maxima. Its primary structure was established as DMYEIKQYKTAHGRPPICAPGEQCPIWV-NH(2), in which two cysteines form a disulfide bond. A FASTA search of SWISS-PROT databank detected a 32% sequence identity between the sequences of the peptide and a segment of rat cocaine- and amphetamine-regulated transcript (CART). Intracerebroventricular (i.c.v.) administration of the peptide induced a significant decrease in food intake in rats, suggesting that it played a role in the control of feeding by brain. Analysis of its cDNA structure revealed that this peptide is coexpressed with bombinakinin M, a bradykinin-related peptide from the same toad. Bombinakinin-GAP appears to be the first example of a novel class of bioactive peptides from amphibian skin, which may be implicated in feeding behavior. |
| 收录类别 | SCI |
| 资助信息 | This work was supported by the grants of “STZ98-3-01”, “Western Light Project” and “Tenth Five Years Plan” pre-research project from the Chinese Academy of Sciences; and grants from the National Natural Science Foundation (30170195) and the Yunnan Science and Technology Commission (2001C0061M) to Dr. Yun Zhang. |
| 原文出处 | 200324199.pdf |
| 语种 | 英语 |
| 公开日期 | 2010-08-24 |
| 源URL | [http://159.226.149.42:8088/handle/152453/2657]  |
| 专题 | 昆明动物研究所_动物活性蛋白多肽组学 昆明动物研究所_动物毒素室 |
| 作者单位 | Department of Animal Toxinology, Kunming Institute of Zoology, The Chinese Academy of Sciences, 32 East Jiao Chang Road, Kunming, Yunnan 650223, PR China |
| 推荐引用方式 GB/T 7714 | Lai R,Liu H,Lee WH,et al. Bombinakinin M gene associated peptide, a novel bioactive peptide from skin secretions of the toad Bombina maxima[J]. PEPTIDES,2003,24(2):199-204. |
| APA | Lai R,Liu H,Lee WH,&Zhang Y[*].(2003).Bombinakinin M gene associated peptide, a novel bioactive peptide from skin secretions of the toad Bombina maxima.PEPTIDES,24(2),199-204. |
| MLA | Lai R,et al."Bombinakinin M gene associated peptide, a novel bioactive peptide from skin secretions of the toad Bombina maxima".PEPTIDES 24.2(2003):199-204. |
入库方式： OAI收割
来源：昆明动物研究所
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