Two novel antimicrobial peptides from skin secretions of the frog, Rana nigrovittata
文献类型：期刊论文
| 作者 | Liu XH1; Liu R1; Wei L1; Yang HL2; Zhang KY1; Liu JZ[*]3; Lai R[*]1,2 |
| 刊名 | JOURNAL OF PEPTIDE SCIENCE
 |
| 出版日期 | 2011 |
| 卷号 | 17期号:1页码:68-72 |
| 关键词 | antimicrobial peptides amphibian skin brevinin-2 Rana nigrovittata |
| 通讯作者 | jzliu21@heinfo.net ; rlai72@njau.edu.cn |
| 合作状况 | 其它 |
| 英文摘要 | Two novel antimicrobial peptides with similarity to brevinin-2 family are purified and characterized from the skin secretions of the frog, Rana nigrovittata. Their amino acid sequences were determined as GAFGNFLKGVAKKAGLKILSIAQCKLSGTC (brevinin-2-RN1) and GAFGNFLKGVAKKAGLKILSIAQCKLFGTC (brevinin-2-RN2), respectively, by Edman degradation. Different from brevinin-2, which is composed of 33 amino acid residues (aa), both brevinin-2-RN1 and -RN2 contain 30 aa. Five cDNA sequences (Genbank accession numbers, EU136465-9) encoding precursors of brevinin-2-RN1 and -RN2 were screened from the skin cDNA library of R. nigrovittata. These precursors are composed of 72 aa including a predicted signal peptide, an acidic spacer peptide, and a mature brevinin-2-RN. Both brevinin-2-RN1 and -RN2 showed strong antimicrobial activities against gram-positive and gram-negative bacteria and fungi. The current work identified and characterized two novel antimicrobial peptides with unique primary structure |
| 收录类别 | SCI |
| 资助信息 | This work was supported by the Chinese Academy of Sciences (KSCX2-YW-G-024), the Ministry of Science and Technology (2010CB529800), and the Ministry of Agriculture (2009ZX08009- 159B). |
| 语种 | 英语 |
| 公开日期 | 2011-01-29 |
| 源URL | [http://159.226.149.42:8088/handle/353002/6562]  |
| 专题 | 昆明动物研究所_动物毒素室 昆明动物研究所_动物模型与人类重大疾病机理重点实验室 |
| 作者单位 | 1.Life Sciences College of Nanjing Agricultural University, Nanjing, Jiangsu 210095,China 2.Key Laboratory of Animal Models and Human Disease Mechanisms, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming650223, Yunnan, China 3.CollegeofLifeSciencesSchoolofHebeiNormalUniversity,Shijiazhuang,Hebei 050016,China |
| 推荐引用方式 GB/T 7714 | Liu XH,Liu R,Wei L,et al. Two novel antimicrobial peptides from skin secretions of the frog, Rana nigrovittata[J]. JOURNAL OF PEPTIDE SCIENCE,2011,17(1):68-72. |
| APA | Liu XH.,Liu R.,Wei L.,Yang HL.,Zhang KY.,...&Lai R[*].(2011).Two novel antimicrobial peptides from skin secretions of the frog, Rana nigrovittata.JOURNAL OF PEPTIDE SCIENCE,17(1),68-72. |
| MLA | Liu XH,et al."Two novel antimicrobial peptides from skin secretions of the frog, Rana nigrovittata".JOURNAL OF PEPTIDE SCIENCE 17.1(2011):68-72. |
入库方式： OAI收割
来源：昆明动物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。