There are Abundant Antimicrobial Peptides in Brains of Two Kinds of Bombina Toads
文献类型：期刊论文
| 作者 | Liu R1; Liu HA2; Ma YF2; Wu J2; Yang HL2; Ye HH3; Lai R[*]1,2 |
| 刊名 | JOURNAL OF PROTEOME RESEARCH
 |
| 出版日期 | 2011 |
| 卷号 | 10期号:4页码:1806-1815 |
| 关键词 | antimicrobial peptides brain amphibian |
| 通讯作者 | rlai72@njau.edu.cn |
| 合作状况 | 其它 |
| 英文摘要 | It is well-known that there is a large amount of antimicrobial peptides in amphibian skins but few antimicrobial peptides are found in amphibian brains. Twenty-two and four antimicrobial peptides were purified and characterized from the brain homogenate of Bombina maxima and B. microdeladigitora, respectively. One hundred fifty-eight cDNA clones encoding 79 antimicrobial peptides were isolated from brain cDNA libraries of B. maxima and B. microdeladigitora. These antimicrobial peptides belong to two peptide groups (maximin and maximin-H). Twenty of them are identical to previously reported antimicrobial peptides (maximin 1-8, 10, 11, maximin H1, 3-5,7, 9, 10, 12, 15, 16) from B. maxima skin secretions. Fifty nine of them are novel antimicrobial peptides. Some of these antimicrobial peptides showed strong antimicrobial activities against tested microorganism strains including Gram-positive and -negative bacteria and fungi. The current diversity in peptide coding cDNA sequences is, to our knowledge, the most extreme yet described for any animal brains. The extreme diversity may give rise to interest to prospect the actual funcitons of antimicrobial peptides in amphibian brains. |
| 收录类别 | SCI |
| 资助信息 | This work was supported by Chinese National Natural 455 Science Foundation (30830021, 30800185, 31025025) and the 456 Ministry of Science and Technology (2010CB529800). |
| 语种 | 英语 |
| 公开日期 | 2011-05-04 |
| 源URL | [http://159.226.149.42:8088/handle/353002/6615]  |
| 专题 | 昆明动物研究所_动物毒素室 昆明动物研究所_动物模型与人类重大疾病机理重点实验室 |
| 作者单位 | 1.Life Sciences College of Nanjing Agricultural University, Nanjing 210095, Jiangsu, China 2.Key Laboratory of Animal Models and Human Disease Mechanisms, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, Yunnan, China 3.Beijing Institute of Microbiology and Epidemiology, the Academy of Military Medical Sciences, China |
| 推荐引用方式 GB/T 7714 | Liu R,Liu HA,Ma YF,et al. There are Abundant Antimicrobial Peptides in Brains of Two Kinds of Bombina Toads[J]. JOURNAL OF PROTEOME RESEARCH,2011,10(4):1806-1815. |
| APA | Liu R.,Liu HA.,Ma YF.,Wu J.,Yang HL.,...&Lai R[*].(2011).There are Abundant Antimicrobial Peptides in Brains of Two Kinds of Bombina Toads.JOURNAL OF PROTEOME RESEARCH,10(4),1806-1815. |
| MLA | Liu R,et al."There are Abundant Antimicrobial Peptides in Brains of Two Kinds of Bombina Toads".JOURNAL OF PROTEOME RESEARCH 10.4(2011):1806-1815. |
入库方式： OAI收割
来源：昆明动物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。