Analgesic and anti-inflammatory effects of the amphibian neurotoxin, anntoxin
文献类型：期刊论文
| 作者 | Wei L1; Dong L2,3; Zhao TY4; You DW2; Liu R1; Hu H2; Yang HL2; Lai R[*]1,2 |
| 刊名 | BIOCHIMIE
 |
| 出版日期 | 2011 |
| 卷号 | 93期号:6页码:995-1000 |
| 关键词 | Amphibian Skin Neurotoxin Analgesic Anti-inflammation |
| 通讯作者 | rlai72@njau.edu.cn |
| 合作状况 | 其它 |
| 英文摘要 | Anntoxin is the first gene-encoded neurotoxin identified from amphibians, which is a 60-residue neurotoxin peptide, acting as an inhibitor of tetrodotoxin-sensitive (TTX-S) voltage-gated sodium channel (VGSC). Sodium channels have been considered as therapeutic targets for pain. Several animal models of persistent inflammatory and neuropathic pain (tail-flick test, hot plate test, acetic acid-induced writhing test, formalin-induced paw licking, carrageenan-induced paw edema) were used to test analgesic functions of recombinant anntoxin (r-anntoxin). In all these animal models, r-anntoxin showed strong analgesic functions. R-anntoxin obviously inhibited secretions of both tumor necrosis factor alpha (TNF-alpha) and cyclooxygenase-2 (COX-2). Histopathological study indicated that r-anntoxin reduced the edematous epidermis induced by carrageenan. All these results indicate that r-anntoxin has strong analgesic and anti-inflammatory activities |
| 收录类别 | SCI |
| 资助信息 | This work was supported by Chinese National Natural Science Foundation (30830021, 30800185, 31025025) and the Ministry of Science and Technology (2010CB529800). |
| 语种 | 英语 |
| 公开日期 | 2011-06-13 |
| 源URL | [http://159.226.149.42:8088/handle/353002/6627]  |
| 专题 | 昆明动物研究所_动物毒素室 昆明动物研究所_动物模型与人类重大疾病机理重点实验室 |
| 作者单位 | 1.Key Laboratory of Microbiological Engineering of Agricultural Environment, Ministry of Agriculture, Life Sciences College of Nanjing Agricultural University, Nanjing 210095, Jiangsu, China 2.Key Laboratory of Animal Models and Human Disease Mechanisms, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, Yunnan, China 3.Graduate School of the Chinese Academy of Sciences, Beijing 100009, China 4.Beijing Institute of Microbiology and Epidemiology, the Academy of Military Medical Sciences, Beijing, China |
| 推荐引用方式 GB/T 7714 | Wei L,Dong L,Zhao TY,et al. Analgesic and anti-inflammatory effects of the amphibian neurotoxin, anntoxin[J]. BIOCHIMIE,2011,93(6):995-1000. |
| APA | Wei L.,Dong L.,Zhao TY.,You DW.,Liu R.,...&Lai R[*].(2011).Analgesic and anti-inflammatory effects of the amphibian neurotoxin, anntoxin.BIOCHIMIE,93(6),995-1000. |
| MLA | Wei L,et al."Analgesic and anti-inflammatory effects of the amphibian neurotoxin, anntoxin".BIOCHIMIE 93.6(2011):995-1000. |
入库方式： OAI收割
来源：昆明动物研究所
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