Proteomics and transcriptome analysis coupled with pharmacological test reveals the diversity of anti-thrombosis proteins from the medicinal insect, Eupolyphaga sinensis
文献类型：期刊论文
| 作者 | Wang Y1,4; Yan HL2; Wang YP1; Yang HL1; Wei L2; Xiao Y1,4; Ye HH3; Lai R[*]1,2; Liu R[*]2 |
| 刊名 | INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY
 |
| 出版日期 | 2012 |
| 卷号 | 42期号:8页码:537-544 |
| 关键词 | Insect Thrombosis Plasminogen-activator Fibrin(ogen)olytic |
| 通讯作者 | rlai@mail.kiz.ac.cn ; liuruisl@163.com |
| 合作状况 | 其它 |
| 英文摘要 | The insect of Eupolyphaga sinensis Walker has been used as traditional anti-thrombosis medicine without bleeding risk for several hundreds years in eastern countries. Our previous work has identified a bifunctional anti-thrombosis protein containing both direct-acting fibrin(ogen)olytic and plasminogen-activating activities from the insect. By proteomics and transcriptome analysis, 105 serine proteases belonging to four families were identified from the ground beetle, E. sinensis and the classification is for serine proteases of this organism. Pharmacological test indicated that 5 (eupolytin 1-5) of them have the abilities to hydrolyze fibrin(ogen) and/or activate plasminogen. The current work revealed the extreme diversity of anti-thrombosis components in E. sinensis and anti-thrombosis molecular mechanisms of the traditional medicinal insect, and provided many templates for the development of new thrombolytic agents. Especially, these proteins, which contain both plasmin- and PA (plasminogen-activating)-like activities, are excellent candidates for anti-thrombosis medicines. |
| 收录类别 | SCI |
| 资助信息 | This work was supported by Chinese National Natural Science Foundation (30830021, 31000962, 31070701, 31025025), the MinistryofScienceandTechnology(2010CB529800,2009ZX09103- 1/091) and the Ministry of Agriculture (2009ZX08009-159B). |
| 语种 | 英语 |
| WOS记录号 | WOS:000306207500002 |
| 公开日期 | 2012-09-04 |
| 源URL | [http://159.226.149.42:8088/handle/152453/7018]  |
| 专题 | 昆明动物研究所_动物毒素室 昆明动物研究所_动物模型与人类重大疾病机理重点实验室 |
| 作者单位 | 1.Key Laboratory of Animal Models and Human Disease Mechanisms, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan 650223, China 2.Key Laboratory of Microbiological Engineering of Agricultural Environment, Ministry of Agriculture, Life Sciences College of Nanjing Agricultural University, 1st Weigang, Nanjing, Jiangsu 210095, China 3.The Academy of Military Medical Sciences, Beijing 100009, China 4.Graduate School of the Chinese Academy of Sciences, Beijing, 100009, China |
| 推荐引用方式 GB/T 7714 | Wang Y,Yan HL,Wang YP,et al. Proteomics and transcriptome analysis coupled with pharmacological test reveals the diversity of anti-thrombosis proteins from the medicinal insect, Eupolyphaga sinensis[J]. INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY,2012,42(8):537-544. |
| APA | Wang Y.,Yan HL.,Wang YP.,Yang HL.,Wei L.,...&Liu R[*].(2012).Proteomics and transcriptome analysis coupled with pharmacological test reveals the diversity of anti-thrombosis proteins from the medicinal insect, Eupolyphaga sinensis.INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY,42(8),537-544. |
| MLA | Wang Y,et al."Proteomics and transcriptome analysis coupled with pharmacological test reveals the diversity of anti-thrombosis proteins from the medicinal insect, Eupolyphaga sinensis".INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY 42.8(2012):537-544. |
入库方式： OAI收割
来源：昆明动物研究所
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