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Bi-functional peptides with both trypsin-inhibitory and antimicrobial activities are frequent defensive molecules in Ranidae amphibian skins

文献类型：期刊论文

作者Yan XW1; Liu H[*]2,3; Yang XN2,3; Che QL1; Liu R2; Yang HL2,3; Liu XH1; You DW2; Wang AL2; Li JX2
刊名AMINO ACIDS
出版日期2012
卷号43期号:1页码:309-316
关键词Amphibian Skin Antimicrobial peptide Innate immunity Protease inhibitor Serine
通讯作者bjx.2007@yahoo.com.cn ; rlai@mail.kiz.ac.cn
合作状况其它
英文摘要Amphibian skins act as the first line against noxious aggression by microorganisms, parasites, and predators. Anti-microorganism activity is an important task of amphibian skins. A large amount of gene-encoded antimicrobial peptides (AMPs) has been identified from amphibian skins. Only a few of small protease inhibitors have been found in amphibian skins. From skin secretions of 5 species (Odorrana livida, Hylarana nigrovittata, Limnonectes kuhlii, Odorrana grahami, and Amolops loloensis) of Ranidae frogs, 16 small serine protease inhibitor peptides have been purified and characterized. They have lengths of 17-20 amino acid residues (aa). All of them are encoded by precursors with length of 65-70 aa. These small peptides show strong trypsin-inhibitory abilities. Some of them can exert antimicrobial activities. They share the conserved GCWTKSXXPKPC fragment in their primary structures, suggesting they belong to the same families of peptide. Signal peptides of precursors encoding these serine protease inhibitors share obvious sequence similarity with those of precursors encoding AMPs from Ranidae frogs. The current results suggest that these small serine protease inhibitors are the common defensive compounds in frog skin of Ranidae as amphibian skin AMPs.
收录类别SCI
资助信息This work was supported by Chinese National Natural Science Foundation (30830021, 30800185, 31025025), the Ministry of Science and Technology (2010CB529800, 2009ZX09103- 1/091) and the Ministry of Agriculture (2009ZX08009-159B).
语种英语
WOS记录号WOS:000305210800031
公开日期2012-09-07
源URL[http://159.226.149.42:8088/handle/152453/7040]  
专题昆明动物研究所_动物毒素室
昆明动物研究所_动物模型与人类重大疾病机理重点实验室
作者单位1.Life Sciences College of Nanjing Agricultural University, Nanjing, Jiangsu 210095, China
2.Key Laboratory of Animal Models and Human Disease Mechanisms, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, 650223 Yunnan, China
3.Graduate School of the Chinese Academy of Sciences, Beijing 100009, China
推荐引用方式
GB/T 7714		 Yan XW,Liu H[*],Yang XN,et al. Bi-functional peptides with both trypsin-inhibitory and antimicrobial activities are frequent defensive molecules in Ranidae amphibian skins[J]. AMINO ACIDS,2012,43(1):309-316.
APA Yan XW.,Liu H[*].,Yang XN.,Che QL.,Liu R.,...&Lai R[*].(2012).Bi-functional peptides with both trypsin-inhibitory and antimicrobial activities are frequent defensive molecules in Ranidae amphibian skins.AMINO ACIDS,43(1),309-316.
MLA Yan XW,et al."Bi-functional peptides with both trypsin-inhibitory and antimicrobial activities are frequent defensive molecules in Ranidae amphibian skins".AMINO ACIDS 43.1(2012):309-316.

入库方式： OAI收割

来源：昆明动物研究所

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