Antimicrobial peptide diversity in the skin of the torrent frog, Amolops jingdongensis
文献类型：期刊论文
| 作者 | He XQ1; Yang SL2; Wei L1; Liu R2; Lai R[*]1,2; Rong MQ[*]1,2 |
| 刊名 | AMINO ACIDS
 |
| 出版日期 | 2013 |
| 卷号 | 44期号:2页码:481-487 |
| 关键词 | Antimicrobial peptides Amphibian Skin Diversity Skin Amolops Amolops |
| 通讯作者 | rlai72@njau.edu.cn ; rongmingqiang@yahoo.com |
| 合作状况 | 其它 |
| 英文摘要 | Antimicrobial peptide diversity has been found in some amphibians. The diversity of antimicrobial peptides may have resulted from the diversity of microorganisms encountered by amphibians. Peptidomics and genomics analyses were used to study antimicrobial peptide diversity in the skin secretions of the torrent frog, Amolops jingdongensis. Thirty-one antimicrobial peptides belonging to nine groups were identified in the skin secretions of this frog. Among them, there are two novel antimicrobial groups (jingdongin-1 and -2) with unique structural motifs. The other seven groups belong to known antimicrobial peptide families, namely brevinin-1, brevinin-2, odorranain-F, esculentin-2, temporin, amolopin-3, and ranacyclin. Combined with previous reports, more than 13 antimicrobial peptide groups have been identified from the genus Amolops. Most of these antimicrobial peptide groups are also found in amphibians belonging to the genus Rana or Odorrana which suggests a possible evolutionary connection among Amolops, Rana, and Odorrana. Two novel antimicrobial groups (jingdongin-1 and -2) were synthesized and their antimicrobial activities were assayed. Some of them showed strong antimicrobial abilities against microorganisms including Gram-negative and -positive bacteria, and fungi. The extreme diversity of antimicrobial peptides in the Amolops amphibians was demonstrated. In addition, several novel peptide templates were provided for antimicrobial agent design. |
| 资助信息 | This work was supported by Chinese National Natural Science Foundation (30830021, 31025025, 31070701, 31000960, 31025025, U1132601), the Ministry of Science and Technology (2010CB529800, 2009ZX09103-1/091, 2011ZX09102- 002-10), the Ministry of Agriculture (2009ZX08009-159B) and Yunnan Province Y103951111. |
| 语种 | 英语 |
| WOS记录号 | WOS:000313794600018 |
| 公开日期 | 2013-03-04 |
| 源URL | [http://159.226.149.42:8088/handle/152453/7223]  |
| 专题 | 昆明动物研究所_动物毒素室 昆明动物研究所_动物模型与人类重大疾病机理重点实验室 |
| 作者单位 | 1.Life Sciences College of Nanjing Agricultural University, Nanjing 210095, Jiangsu, China 2.Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunan Provinces, Kunming Institute of Zoology, Kunming 650223, Yunnan, China |
| 推荐引用方式 GB/T 7714 | He XQ,Yang SL,Wei L,et al. Antimicrobial peptide diversity in the skin of the torrent frog, Amolops jingdongensis[J]. AMINO ACIDS,2013,44(2):481-487. |
| APA | He XQ,Yang SL,Wei L,Liu R,Lai R[*],&Rong MQ[*].(2013).Antimicrobial peptide diversity in the skin of the torrent frog, Amolops jingdongensis.AMINO ACIDS,44(2),481-487. |
| MLA | He XQ,et al."Antimicrobial peptide diversity in the skin of the torrent frog, Amolops jingdongensis".AMINO ACIDS 44.2(2013):481-487. |
入库方式： OAI收割
来源：昆明动物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。