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Chemical Punch Packed in Venoms Makes Centipedes Excellent Predators
文献类型：期刊论文
| 作者 | Yang S1,5; Liu ZH2; Xiao Y1,5; Li Y1; Rong MQ1; Liang SP2; Zhang ZY1,5; Yu HN4; King GF[*]3; Lai R[*]1 |
| 刊名 | MOLECULAR & CELLULAR PROTEOMICS
 |
| 出版日期 | 2012 |
| 卷号 | 11期号:9页码:640-650 |
| 通讯作者 | glenn.king@imb.uq.edu.au ; rlai@mail.kiz.ac.cn |
| 合作状况 | 其它 |
| 英文摘要 | Centipedes are excellent predatory arthropods that inject venom to kill or immobilize their prey. Although centipedes have long been known to be venomous, their venoms remain largely unexplored. The chemical components responsible for centipede predation and the functional mechanisms are unknown. Twenty-six neurotoxin-like peptides belonging to ten groups were identified from the centipede venoms, Scolopendra subspinipes mutilans L. Koch by peptidomics combined with transcriptome analysis, revealing the diversity of neurotoxins. These neurotoxins each contain two to four intramolecular disulfide bridges, and in most cases the disulfide framework is different from that found in neurotoxins from the venoms of spiders, scorpions, marine cone snails, sea anemones, and snakes (5S animals). Several neurotoxins contain potential insecticidal abilities, and they are found to act on voltage-gated sodium, potassium, and calcium channels, respectively. Although these neurotoxins are functionally similar to the disulfide-rich neurotoxins found in the venoms of 5S animals in that they modulate the activity of voltage-gated ion channels, in almost all cases the primary structures of the centipede venom peptides are unique. This represents an interesting case of convergent evolution in which different venomous animals have evolved different molecular strategies for targeting the same ion channels in prey and predators. Moreover, the high level of biochemical diversity revealed in this study suggests that centipede venoms might be attractive subjects for prospecting and screening for peptide candidates with potential pharmaceutical or agrochemical applications. Molecular & Cellular Proteomics 11: 10.1074/mcp.M112.018853, 640-650, 2012. |
| 收录类别 | SCI |
| 资助信息 | This work was supported by Ministry of Science and Technology Grant 2010CB529800; Chinese National Natural Science Foundation Grants 31070701, 31000962, and 31025025; Ministry of Agriculture Grant 2009ZX08009–159B; Chinese Academy of Sciences Grants KSCX2-EW-J-23 and KSCX2-EW-R-11; and funds from the Key Lab- oratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan Province. |
| 语种 | 英语 |
| WOS记录号 | WOS:000310209300009 |
| 公开日期 | 2013-04-09 |
| 源URL | [http://159.226.149.42:8088/handle/152453/7317]  |
| 专题 | 昆明动物研究所_动物毒素室 昆明动物研究所_动物模型与人类重大疾病机理重点实验室 |
| 作者单位 | 1.Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Kunming 650223, Yunnan, China 2.Key Laboratory of Protein Chemistry and Developmental Biology of Ministry of Education, College of Life Sciences, Hunan Normal Univer- sity, Changsha 410081, China 3.Institute for Molecular Bioscience, The University of Queensland, St. Lucia, Queensland 4072, Australia 4.College of Life Sciences School of Heibei Normal University, Shijiazhuang, Hebei, 050016 China 5.Graduate School of Chi- nese Academy of Sciences, Beijing100009, China |
| 推荐引用方式 GB/T 7714 | Yang S,Liu ZH,Xiao Y,et al. Chemical Punch Packed in Venoms Makes Centipedes Excellent Predators[J]. MOLECULAR & CELLULAR PROTEOMICS,2012,11(9):640-650. |
| APA | Yang S.,Liu ZH.,Xiao Y.,Li Y.,Rong MQ.,...&Lai R[*].(2012).Chemical Punch Packed in Venoms Makes Centipedes Excellent Predators.MOLECULAR & CELLULAR PROTEOMICS,11(9),640-650. |
| MLA | Yang S,et al."Chemical Punch Packed in Venoms Makes Centipedes Excellent Predators".MOLECULAR & CELLULAR PROTEOMICS 11.9(2012):640-650. |
入库方式： OAI收割
来源：昆明动物研究所
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