A novel frog skin peptide containing function to induce muscle relaxation
文献类型：期刊论文
| 作者 | Meng P1; Wei L1; Yang SL2; Liu H2; Liu R[*]2; Lai R[*]1,2 |
| 刊名 | BIOCHIMIE
 |
| 出版日期 | 2012 |
| 卷号 | 94期号:12页码:2508-2513 |
| 关键词 | Amphibian Skin Myotropic peptide Polypedates pingbianensis Tree frog |
| 通讯作者 | liurui@mail.kiz.ac.cn ; rlai72@njau.edu.cn |
| 合作状况 | 其它 |
| 英文摘要 | A novel bioactive peptide (polypedarelaxin 1) was identified from the skin secretions of the tree frog, Polypedates pingbianensis. Polypedarelaxin 1 is composed of 21 amino acid residues with a sequence of QGGLLGKVSNLANDALGILPI. Its primary structure was further confirmed by cDNA cloning and mass spectrometry analysis. Polypedarelaxin 1 was found to elicit concentration-dependent relaxation effects on isolated rat ileum. It has no antimicrobial and serine protease inhibitory activities. BLAST search revealed that polypedarelaxin 1 did not show similarity to known proteins or peptides. Especially, polypedarelaxin 1 do not contain conserved structural motifs of other amphibian myotropic peptides, such as bradykinins, bombesins, cholecystokinin (CCK), and tachykinins, indicating that polypedarelaxin 1 belongs to a novel family of amphibian myotropic peptide. (C) 2012 Elsevier Masson SAS. |
| 收录类别 | SCI |
| 资助信息 | This work was supported by Chinese National Natural Science Foundation (30830021, 31025025, 31070701, 31000960, U1132601), the Ministry of Science and Technology (2010CB529800, 2009ZX09103-1/091, 2011ZX09102-002-10), the Ministry of Agriculture (2009ZX08009-159B) and Yunnan Province (Y103951111). |
| 语种 | 英语 |
| WOS记录号 | WOS:000312517800007 |
| 公开日期 | 2013-09-17 |
| 源URL | [http://159.226.149.42:8088/handle/152453/7640]  |
| 专题 | 昆明动物研究所_动物毒素室 昆明动物研究所_动物模型与人类重大疾病机理重点实验室 |
| 作者单位 | 1.Life Sciences College of Nanjing Agricultural University, 1st Weigang, Nanjing 210095, Jiangsu, China 2.Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences & Yunan Provinces, Kunming Institute of Zoology, Kunming 650223, Yunnan, China |
| 推荐引用方式 GB/T 7714 | Meng P,Wei L,Yang SL,et al. A novel frog skin peptide containing function to induce muscle relaxation[J]. BIOCHIMIE,2012,94(12):2508-2513. |
| APA | Meng P,Wei L,Yang SL,Liu H,Liu R[*],&Lai R[*].(2012).A novel frog skin peptide containing function to induce muscle relaxation.BIOCHIMIE,94(12),2508-2513. |
| MLA | Meng P,et al."A novel frog skin peptide containing function to induce muscle relaxation".BIOCHIMIE 94.12(2012):2508-2513. |
入库方式： OAI收割
来源：昆明动物研究所
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