A novel bioactive peptide from wasp venom
文献类型：期刊论文
| 作者 | Chen LL1,2; Chen WL1,3; Yang HL1; Lai R[*]1 |
| 刊名 | Journal of venom research
 |
| 出版日期 | 2010 |
| 卷号 | 1期号:X页码:43-47 |
| 关键词 | Vespa magnifica Wasp venom contraction novel peptide smooth muscle |
| 通讯作者 | rlai@mail.kiz.ac.cn |
| 合作状况 | 其它 |
| 英文摘要 | Wasp venoms contain a number of pharmacologically active biomolecules, undertaking a wide range of functions necessary for the wasp's survival. We purified and characterized a novel bioactive peptide (vespin) from the venoms of Vespa magnifica (Smith) wasps with unique primary structure. Its amino acid sequence was determined to be CYQRRVAITAGGLKHRLMSSLIIIIIIRINYLRDNSVIILESSY. It has 44 residues including 15 leucines or isoleucines (32%) in the sequence. Vespin showed contractile activity on isolated ileum smooth muscle. The cDNA encoding vespin precursor was cloned from the cDNA library of the venomous glands. The precursor consists of 67 amino acid residues including the predicted signal peptide and mature vespin. A di-basic enzymatic processing site (-KR-) is located between the signal peptide and the mature peptide. Vespin did not show similarity with any known proteins or peptides by BLAST search, suggesting it is a novel bioactive peptide from wasp venoms. |
| 收录类别 | SCI |
| 资助信息 | This work was supported by the Chinese Academy of Sci- ences (KSCX2-YW-G-024), the Ministry of Science and Technology (2010CB529800) and the Ministry of Agricul- ture (2009ZX08009-159B). |
| 语种 | 英语 |
| 公开日期 | 2013-09-18 |
| 源URL | [http://159.226.149.42:8088/handle/152453/7649]  |
| 专题 | 昆明动物研究所_动物毒素室 |
| 作者单位 | 1.Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, Yunnan, China 2.Clinical Laboratory, the First Affiliated Hospital of Kunming Medical College, Kunming 650032, Yunnan, China 3.Yunnan Clinical Research Center of Breast Cancer, the Third Affi liated Hospital of Kunming Medical College, Kunming 650032, Yunnan, China |
| 推荐引用方式 GB/T 7714 | Chen LL,Chen WL,Yang HL,et al. A novel bioactive peptide from wasp venom[J]. Journal of venom research,2010,1(X):43-47. |
| APA | Chen LL,Chen WL,Yang HL,&Lai R[*].(2010).A novel bioactive peptide from wasp venom.Journal of venom research,1(X),43-47. |
| MLA | Chen LL,et al."A novel bioactive peptide from wasp venom".Journal of venom research 1.X(2010):43-47. |
入库方式： OAI收割
来源：昆明动物研究所
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