A Small Peptide with Therapeutic Potential for Inflammatory Acne Vulgaris
文献类型：期刊论文
| 作者 | Zhang ZY1,3; Mu LX1,3; Tang J1,3; Duan ZL1,3; Wang FY2; Wei L2; Rong MQ1; Lai R[*]1 |
| 刊名 | PLOS ONE
 |
| 出版日期 | 2013 |
| 卷号 | 8期号:8页码:e72923 |
| 通讯作者 | rlai@mail.kiz.ac.cn |
| 合作状况 | 其它 |
| 英文摘要 | A designed peptide named LZ1 with 15 amino acid residues containing strong antimicrobial activity against bacteria pathogens of acne vulgaris including Propionibacterium acnes, Staphylococcus epidermidis and S. aureus. Especially, it exerted strong anti-P. acnes ability. The minimal inhibitory concentration against three strains of P. acnes was only 0.6 mu g/ml, which is 4 times lower than that of clindamycin. In experimental mice skin colonization model, LZ1 significantly reduced the number of P. acnes colonized on the ear, P. acnes-induced ear swelling, and inflammatory cell infiltration. It ameliorated inflammation induced by P. acnes by inhibiting the secretion of inflammatory factors including tumor necrosis factor-alpha (TNF-alpha) and interleukin (IL)-1 beta. LZ1 showed little cytotoxicity on human keratinocyte and hemolytic activity on human blood red cells. Furthermore, LZ1 was very stable in human plasma. Combined with its potential bactericidal and anti-inflammatory properties, simple structure and high stability, LZ1 might be an ideal candidate for the treatment of acne. |
| 收录类别 | SCI |
| 资助信息 | This work was supported by Ministry of Science and Technology (2010CB529800, 2013CB911300), National Natural Science Foundation (30830021, 31025025, 31070701, 31000960, 31025025, U1132601, 31200590), and Yunnan Province (2011CI139, 2012BC009). |
| 语种 | 英语 |
| WOS记录号 | WOS:000323733800086 |
| 公开日期 | 2013-09-29 |
| 源URL | [http://159.226.149.42:8088/handle/152453/7686]  |
| 专题 | 昆明动物研究所_动物毒素室 昆明动物研究所_动物模型与人类重大疾病机理重点实验室 |
| 作者单位 | 1.Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Kunming, Yunnan, China 2.Life Sciences College of Nanjing Agricultural University, 1st Weigang, Nanjing, Jiangsu, China 3.University of Chinese Academy of Sciences, Beijing, China |
| 推荐引用方式 GB/T 7714 | Zhang ZY,Mu LX,Tang J,et al. A Small Peptide with Therapeutic Potential for Inflammatory Acne Vulgaris[J]. PLOS ONE,2013,8(8):e72923. |
| APA | Zhang ZY.,Mu LX.,Tang J.,Duan ZL.,Wang FY.,...&Lai R[*].(2013).A Small Peptide with Therapeutic Potential for Inflammatory Acne Vulgaris.PLOS ONE,8(8),e72923. |
| MLA | Zhang ZY,et al."A Small Peptide with Therapeutic Potential for Inflammatory Acne Vulgaris".PLOS ONE 8.8(2013):e72923. |
入库方式： OAI收割
来源：昆明动物研究所
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