The First Salamander Defensin Antimicrobial Peptide
文献类型：期刊论文
| 作者 | Meng P1; Yang SL2; Shen CB2; Jiang K3; Rong MQ[*]2; Lai R[*]1,2 |
| 刊名 | PLOS ONE
 |
| 出版日期 | 2013 |
| 卷号 | 8期号:12页码:e83044 |
| 通讯作者 | rlai72@njau.edu.cn ; rongmingqiang@mail.kiz.ac.cn |
| 合作状况 | 其它 |
| 英文摘要 | Antimicrobial peptides have been widely identified from amphibian skins except salamanders. A novel antimicrobial peptide (CFBD) was isolated and characterized from skin secretions of the salamander, Cynops fudingensis. The cDNA encoding CFBD precursor was cloned from the skin cDNA library of C. fudingensis. The precursor was composed of three domains: signal peptide of 17 residues, mature peptide of 41 residues and intervening propeptide of 3 residues. There are six cysteines in the sequence of mature CFBD peptide, which possibly form three disulfide-bridges. CFBD showed antimicrobial activities against Staphylococcus aureus, Bacillus subtilis, Candida albicans and Escherichia coli. This peptide could be classified into family of beta-defensin based on its seqeuence similarity with beta-defensins from other vertebrates. Evolution analysis indicated that CFBD was close to fish beta-defensin. As far as we know, CFBD is the first beta-defensin antimicrobial peptide from salamanders. |
| 收录类别 | SCI |
| 资助信息 | This work was supported by Chinese National Natural Science Foundation (30830021, 31025025, 31070701, 31000960, 31025025, U1132601, 31200590), the Ministry of Science and Technology (2010CB529800, 2011ZX09102-002-10), Yunnan Province (2011CI139, 2012BC009,2013FB072), Jiangsu Province (BK2012365, BE2012748). |
| 语种 | 英语 |
| WOS记录号 | WOS:000329194700024 |
| 公开日期 | 2014-02-11 |
| 源URL | [http://159.226.149.42:8088/handle/152453/7795]  |
| 专题 | 昆明动物研究所_两栖爬行类多样性与进化 昆明动物研究所_动物模型与人类重大疾病机理重点实验室 昆明动物研究所_遗传资源与进化国家重点实验室 昆明动物研究所_动物毒素室 |
| 作者单位 | 1.Life Sciences College of Nanjing Agricultural University, Nanjing,Jiangsu, China 2.Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Kunming, Yunnan, China 3.State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, China |
| 推荐引用方式 GB/T 7714 | Meng P,Yang SL,Shen CB,et al. The First Salamander Defensin Antimicrobial Peptide[J]. PLOS ONE,2013,8(12):e83044. |
| APA | Meng P,Yang SL,Shen CB,Jiang K,Rong MQ[*],&Lai R[*].(2013).The First Salamander Defensin Antimicrobial Peptide.PLOS ONE,8(12),e83044. |
| MLA | Meng P,et al."The First Salamander Defensin Antimicrobial Peptide".PLOS ONE 8.12(2013):e83044. |
入库方式： OAI收割
来源：昆明动物研究所
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