中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
首页 机构 成果 学者
  
  1. CAS IR Grid
  2. 昆明动物研究所
  3. 昆明动物研究所
  4. 动物模型与人类重大疾病机理重点实验室
  5. 动物毒素室
Novel analgesic peptides from the tree frog of Hyla japonica

文献类型：期刊论文

作者Zhu YQ1; Li ZT3; Liu H2,5; He XQ1; Zhang Y2; Jin JQ2; Che J2; Li C4; Chen WL6; Lai R[*]1,2
刊名BIOCHIMIE
出版日期2014
卷号99期号:X页码:38-43
关键词Amphibian Skin Analgesic Peptide Defensive
通讯作者rlai72@njau.edu.cn ; liujingze@mail.hebtu.edu.cn
合作状况其它
英文摘要Two novel analgesic peptides (Analgesin-HJ, FWPVI-NH2 and Analgesin-HJ(I5T), FWPVT-NH2) were identified from the skin of the tree frog, Hyla japonica. There are 171 amino acid residues in the precursor encoding analgesin-HJs. The precursor contains 10 copies of mature peptide, which include 9 copies of analgesin-HJ and one copy of analgesin-HJ(I5T). Results from analgesic experiments using mice models including abdominal writhing induced by acetic acid, formalin-induced paw licking, and thermal pain test indicated that this two peptides exerted comparable analgesic activities with morphine. In addition, they had ability to inhibit inflammatory factor secretion induced by lipopolysaccharides (LPS). Considering their easy production, storage, transfer and potential analgesic activity, analgesin-HJs might be exciting leading compounds or templates for the development of novel analgesic agent. In addition, this study might facilitate to understand skin defensive mechanism of amphibians.
收录类别SCI
资助信息This work was supported by Ministry of Science and Technology (2010CB529800, 2013CB911300), National Natural Science Foun- dation (31025025, U1132601, 31200590, 31260208), CAS (KJZD- EW-L03) and Yunnan Province (2011CI139, 2012BC009).
语种英语
WOS记录号WOS:000332822100005
公开日期2014-04-18
源URL[http://159.226.149.42:8088/handle/152453/7841]  
专题昆明动物研究所_动物毒素室
昆明动物研究所_动物模型与人类重大疾病机理重点实验室
昆明动物研究所_动物活性蛋白多肽组学
昆明动物研究所_两栖爬行类多样性与进化
作者单位1.Life Sciences College of Nanjing Agricultural University, Nanjing 210095, Jiangsu, China
2.Key Laboratory of Animal Models and Human Disease Mechanisms, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, Yunnan, China
3.College of Life Sciences, Hebei Normal University, Shijiazhuang 050024, Hebei, Chin
4.Huangnihe National Nature Reserve, Tonghua 134000, Jilin, China
5.Graduate University of Chinese Academy of Sciences, Beijing 100009, China
6.Yunnan Clinical Research Center of Breast Cancer, The Third Affiliated Hospital of Kunming Medical College, Kunming 650032, China
推荐引用方式
GB/T 7714		 Zhu YQ,Li ZT,Liu H,et al. Novel analgesic peptides from the tree frog of Hyla japonica[J]. BIOCHIMIE,2014,99(X):38-43.
APA Zhu YQ.,Li ZT.,Liu H.,He XQ.,Zhang Y.,...&Liu JZ[*].(2014).Novel analgesic peptides from the tree frog of Hyla japonica.BIOCHIMIE,99(X),38-43.
MLA Zhu YQ,et al."Novel analgesic peptides from the tree frog of Hyla japonica".BIOCHIMIE 99.X(2014):38-43.

入库方式： OAI收割

来源：昆明动物研究所

浏览0
下载0
收藏0
其他版本

除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。