Novel analgesic peptides from the tree frog of Hyla japonica
文献类型:期刊论文
作者 | Zhu YQ1; Li ZT3; Liu H2,5; He XQ1; Zhang Y2; Jin JQ2; Che J2; Li C4; Chen WL6; Lai R[*]1,2 |
刊名 | BIOCHIMIE
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出版日期 | 2014 |
卷号 | 99期号:X页码:38-43 |
关键词 | Amphibian Skin Analgesic Peptide Defensive |
通讯作者 | rlai72@njau.edu.cn ; liujingze@mail.hebtu.edu.cn |
合作状况 | 其它 |
英文摘要 | Two novel analgesic peptides (Analgesin-HJ, FWPVI-NH2 and Analgesin-HJ(I5T), FWPVT-NH2) were identified from the skin of the tree frog, Hyla japonica. There are 171 amino acid residues in the precursor encoding analgesin-HJs. The precursor contains 10 copies of mature peptide, which include 9 copies of analgesin-HJ and one copy of analgesin-HJ(I5T). Results from analgesic experiments using mice models including abdominal writhing induced by acetic acid, formalin-induced paw licking, and thermal pain test indicated that this two peptides exerted comparable analgesic activities with morphine. In addition, they had ability to inhibit inflammatory factor secretion induced by lipopolysaccharides (LPS). Considering their easy production, storage, transfer and potential analgesic activity, analgesin-HJs might be exciting leading compounds or templates for the development of novel analgesic agent. In addition, this study might facilitate to understand skin defensive mechanism of amphibians. |
收录类别 | SCI |
资助信息 | This work was supported by Ministry of Science and Technology (2010CB529800, 2013CB911300), National Natural Science Foun- dation (31025025, U1132601, 31200590, 31260208), CAS (KJZD- EW-L03) and Yunnan Province (2011CI139, 2012BC009). |
语种 | 英语 |
WOS记录号 | WOS:000332822100005 |
公开日期 | 2014-04-18 |
源URL | [http://159.226.149.42:8088/handle/152453/7841] ![]() |
专题 | 昆明动物研究所_动物毒素室 昆明动物研究所_动物模型与人类重大疾病机理重点实验室 昆明动物研究所_动物活性蛋白多肽组学 昆明动物研究所_两栖爬行类多样性与进化 |
作者单位 | 1.Life Sciences College of Nanjing Agricultural University, Nanjing 210095, Jiangsu, China 2.Key Laboratory of Animal Models and Human Disease Mechanisms, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, Yunnan, China 3.College of Life Sciences, Hebei Normal University, Shijiazhuang 050024, Hebei, Chin 4.Huangnihe National Nature Reserve, Tonghua 134000, Jilin, China 5.Graduate University of Chinese Academy of Sciences, Beijing 100009, China 6.Yunnan Clinical Research Center of Breast Cancer, The Third Affiliated Hospital of Kunming Medical College, Kunming 650032, China |
推荐引用方式 GB/T 7714 | Zhu YQ,Li ZT,Liu H,et al. Novel analgesic peptides from the tree frog of Hyla japonica[J]. BIOCHIMIE,2014,99(X):38-43. |
APA | Zhu YQ.,Li ZT.,Liu H.,He XQ.,Zhang Y.,...&Liu JZ[*].(2014).Novel analgesic peptides from the tree frog of Hyla japonica.BIOCHIMIE,99(X),38-43. |
MLA | Zhu YQ,et al."Novel analgesic peptides from the tree frog of Hyla japonica".BIOCHIMIE 99.X(2014):38-43. |
入库方式: OAI收割
来源:昆明动物研究所
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