A Small Peptide with Potential Ability to Promote Wound Healing
文献类型：期刊论文
| 作者 | Tang J1,4; Liu H1,4; Gao C3; Mu LX1,4; Yang SL1,4; Rong MQ1; Zhang ZY1,4; Liu J1,4; Ding Q[*]2; Lai R[*]1 |
| 刊名 | PLOS ONE
 |
| 出版日期 | 2014 |
| 卷号 | 9期号:3页码:e92082 |
| 通讯作者 | dqnj2000@aliyun.com ; rlai@mail.kiz.ac.cn |
| 英文摘要 | Wound-healing represents a major health burden, such as diabetes-induced skin ulcers and burning. Many works are being tried to find ideal clinical wound-healing biomaterials. Especially, small molecules with low cost and function to promote production of endogenous wound healing agents (i.e. transforming growth factor beta, TGF-beta) are excellent candidates. In this study, a small peptide (tiger17, c[WCKPKPKPRCH-NH2]) containing only 11 amino acid residues was designed and proved to be a potent wound healer. It showed strong wound healing-promoting activity in a murine model of full thickness dermal wound. Tiger17 exerted significant effects on three stages of wound healing progresses including (1) the induction of macrophages recruitment to wound site at inflammatory reaction stage; (2) the promotion of the migration and proliferation both keratinocytes and fibroblasts, leading to reepithelialization and granulation tissue formation; and (3) tissue remodeling phase, by promoting the release of transforming TGF-beta 1 and interleukin 6 (IL-6) in murine macrophages and activating mitogen-activated protein kinases (MAPK) signaling pathways. Considering its easy production, store and transfer and function to promote production of endogenous wound healing agents (TGF-beta), tiger17 might be an exciting biomaterial or template for the development of novel wound-healing agents. |
| 资助信息 | This work was supported by Ministry of Science and Technology (2010CB529800, 2013CB911300), National Natural Science Foundation (30830021, 31025025, 31070701, 31000960, 31025025, U1132601, 31200590), and Yunnan Province (2011CI139, 2012BC009) |
| 语种 | 英语 |
| WOS记录号 | WOS:000333348500081 |
| 公开日期 | 2014-06-03 |
| 源URL | [http://159.226.149.42:8088/handle/152453/7855]  |
| 专题 | 昆明动物研究所_动物毒素室 昆明动物研究所_动物模型与人类重大疾病机理重点实验室 |
| 作者单位 | 1.Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Kunming, Yunnan, China 2.Department of Breast Surgery, the First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China 3.College of Veterinary Medicine of Jiangsu Animal Husbandry and Veterinary College, Taizhou, Jiangsu, China 4.Graduate University of Chinese Academy of Sciences, Beijing, China |
| 推荐引用方式 GB/T 7714 | Tang J,Liu H,Gao C,et al. A Small Peptide with Potential Ability to Promote Wound Healing[J]. PLOS ONE,2014,9(3):e92082. |
| APA | Tang J.,Liu H.,Gao C.,Mu LX.,Yang SL.,...&Lai R[*].(2014).A Small Peptide with Potential Ability to Promote Wound Healing.PLOS ONE,9(3),e92082. |
| MLA | Tang J,et al."A Small Peptide with Potential Ability to Promote Wound Healing".PLOS ONE 9.3(2014):e92082. |
入库方式： OAI收割
来源：昆明动物研究所
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