热门
A potential wound-healing-promoting peptide from salamander skin
文献类型：期刊论文
| 作者 | Mu LX1,2; Tang J1,2; Liu H1,2; Shen CB1,2; Rong MQ1; Zhang ZY1,2; Lai R[*]1 |
| 刊名 | FASEB JOURNAL
 |
| 出版日期 | 2014 |
| 卷号 | 28期号:9页码:3919-3929 |
| 关键词 | TGF-beta urodele amphibians full-thickness incision reepithelialization |
| 通讯作者 | rlai@mail.kiz.ac.cn |
| 英文摘要 | Although it is well known that wound healing proceeds incredibly quickly in urodele amphibians, such as newts and salamanders, little is known about skin-wound healing, and no bioactive/effector substance that contributes to wound healing has been identified from these animals. As a step toward understanding salamander wound healing and skin regeneration, a potential wound-healing-promoting peptide (tylotoin; KCVRQNNKRVCK) was identified from salamander skin of Tylototriton verrucosus. It shows comparable wound-healing-promoting ability (EC50 = 11.14 mu g/ml) with epidermal growth factor (EGF; NSDSECPLSHDGYCLHDGVCMYIEALDKYACNCVVGYIGERCQYRDL-KWWELR) in a murine model of full-thickness dermal wound. Tylotoin directly enhances the motility and proliferation of keratinocytes, vascular endothelial cells, and fibroblasts, resulting in accelerated reepithelialization and granulation tissue formation in the wound site. Tylotoin also promotes the release of transforming growth factor beta 1 (TGF-beta 1) and interleukin 6 (IL-6), which are essential in the wound healing response. Gene-encoded tylotoin secreted in salamander skin is possibly an effector molecule for skin wound healing. This study may facilitate understanding of the cellular and molecular events that underlie quick wound healing in salamanders. |
| 资助信息 | This work was supported by the Ministry of Science and Technology (2010CB529800, 2013CB911300), the Na- tional Natural Science Foundation (31025025, U1132601, U1302221, 31200590, 31260208), and Jiangsu Province (BK2012365, BE2012748). |
| 语种 | 英语 |
| WOS记录号 | WOS:000340845900010 |
| 公开日期 | 2014-10-10 |
| 源URL | [http://159.226.149.42:8088/handle/152453/8020]  |
| 专题 | 昆明动物研究所_动物毒素室 昆明动物研究所_动物模型与人类重大疾病机理重点实验室 |
| 作者单位 | 1.Key Laboratory of Animal Models and Human Disease Mechanisms, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, China 2.Kunming College of Life Science, University of Chinese Academy of Sciences, Beijing, China |
| 推荐引用方式 GB/T 7714 | Mu LX,Tang J,Liu H,et al. A potential wound-healing-promoting peptide from salamander skin[J]. FASEB JOURNAL,2014,28(9):3919-3929. |
| APA | Mu LX.,Tang J.,Liu H.,Shen CB.,Rong MQ.,...&Lai R[*].(2014).A potential wound-healing-promoting peptide from salamander skin.FASEB JOURNAL,28(9),3919-3929. |
| MLA | Mu LX,et al."A potential wound-healing-promoting peptide from salamander skin".FASEB JOURNAL 28.9(2014):3919-3929. |
入库方式： OAI收割
来源：昆明动物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。