A short peptide from frog skin accelerates diabetic wound healing
文献类型：期刊论文
| 作者 | Liu H1,2; Duan ZL1,2; Tang J1,2; Lv QM1; Rong MQ1; Lai R[*]1 |
| 刊名 | FEBS JOURNAL
 |
| 出版日期 | 2014 |
| 卷号 | 281期号:20页码:4633-4643 |
| 关键词 | amphibian angiogenesis anti-inflammatory diabetic wounds wound healing |
| 通讯作者 | rlai@mail.kiz.ac.cn |
| 合作状况 | 其它 |
| 英文摘要 | elayed wound healing will result in the development of chronic wounds in some diseases, such as diabetes. Amphibian skins possess excellent wound-healing ability and represent a resource for prospective wound-healing promoting compounds. A potential wound-healing promoting peptide (CW49; amino acid sequence APFRMGICTTN) was identified from the frog skin of Odorranagrahami. It promotes wound healing in a murine model with a full-thickness dermal wound in both normal and diabetic animals. In addition to its strong angiogenic ability with respect to the upregulation of some angiogenic proteins, CW49 also showed a significant anti-inflammatory effect in diabetic wounds, which was very important for healing chronic wounds. CW49 had little effect on re-epithelialization, resulting in no significant effect on wound closure rate compared to a vehicle control. Altogether, this indicated that CW49 might accelerate diabetic wound healing by promoting angiogenesis and preventing any excessive inflammatory response. Considering its favorable traits as a small peptide that significantly promotes angiogenesis, CW49 might be an excellent candidate or template for the development of a drug for use in the treatment of diabetic wounds. |
| 收录类别 | SCI |
| 资助信息 | This work was supported by the Ministry of Science and Technology (2010CB529800, 2013CB911300), National Natural Science Foundation (31025025, 31025025, U1132601, U1302221, 31200590) and Yun- nan Province (2011CI139, 2012BC009). |
| 语种 | 英语 |
| WOS记录号 | WOS:000343918500007 |
| 公开日期 | 2014-10-29 |
| 源URL | [http://159.226.149.42:8088/handle/152453/8158]  |
| 专题 | 昆明动物研究所_动物毒素室 昆明动物研究所_动物模型与人类重大疾病机理重点实验室 |
| 作者单位 | 1.Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Yunnan, China 2.Graduate University of Chinese Academy of Sciences, Beijing, China |
| 推荐引用方式 GB/T 7714 | Liu H,Duan ZL,Tang J,et al. A short peptide from frog skin accelerates diabetic wound healing[J]. FEBS JOURNAL,2014,281(20):4633-4643. |
| APA | Liu H,Duan ZL,Tang J,Lv QM,Rong MQ,&Lai R[*].(2014).A short peptide from frog skin accelerates diabetic wound healing.FEBS JOURNAL,281(20),4633-4643. |
| MLA | Liu H,et al."A short peptide from frog skin accelerates diabetic wound healing".FEBS JOURNAL 281.20(2014):4633-4643. |
入库方式： OAI收割
来源：昆明动物研究所
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