A potent anti-thrombosis peptide (vasotab TY) from horsefly salivary glands
文献类型：期刊论文
| 作者 | Zhang ZY1,3; Gao L2; Shen CB1,3; Rong MQ1; Yan XW2; Lai R[*]1,2 |
| 刊名 | INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
 |
| 出版日期 | 2014 |
| 卷号 | 54期号:X页码:83-88 |
| 关键词 | Anti-thrombosis Glycoprotein IIb/IIIa Horsefly Platelet inhibitor Vasodilator |
| 通讯作者 | rlai@mail.kiz.ac.cn |
| 合作状况 | 其它 |
| 英文摘要 | Vasotab TY is a KGD (Lys-Gly-Asp)-containing peptide identified from salivary glands of the horsefly of Tabanus yao. We have previously reported that vasotab TY showed a strong vasodilator activity. In the present study, vasotab TY was found to inhibit platelet aggregation effectively. It completely inhibited platelet aggregation induced by adenosine diphosphate (ADP) at the concentration of 9.6 mu,g/ml. Vasotab TY significantly reduced thrombus weight in rat arteriovenous shunt model and inhibited thrombosis in carrageenan-induced mouse tail thrombosis model in vivo. Vasotab TV competitively bound to glycoprotein IIb/IIIa (GPIIb/IIIa) with eptifibatide, a well-known KGD-containing cyclic heptapeptide containing high specificity and high affinity for GPIIb/IIIa, suggesting that it is an antagonist of the fibrinogen receptor GPIIb/IIIa on the surface of platelet. The KGD motif in vasotab TY may facilitate the binding of it to GPIIb/IIIa. Vasotab TY showed a half-life of more. than 1 h in vivo. It showed little side effects including little bleeding, no hemolytic activity on human blood red cells and no cytotoxicity on human keratinocyte and THP-1 cells. Combined its vasodilator and platelet inhibitory functions, vasotab TY might be an excellent candidate for the development of clinical anti-thrombosis medicines. |
| 收录类别 | SCI |
| 资助信息 | This work was supported by Ministry of Science and Tech- nology (2010CB529800, 2013CB911300), National Natural Science Foundation (31025025, U1132601, 31200590, 31201717), Chi- nese Academy of Sciences (KSZD-EW-Z-007) and Jiangsu Province (BK2012365, BE2012748, CXZZ11 0649). |
| 语种 | 英语 |
| WOS记录号 | WOS:000342524600010 |
| 公开日期 | 2014-11-21 |
| 源URL | [http://159.226.149.42:8088/handle/152453/8177]  |
| 专题 | 昆明动物研究所_动物毒素室 昆明动物研究所_动物模型与人类重大疾病机理重点实验室 |
| 作者单位 | 1.Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Kunming 650223, Yunnan, China 2.Life Sciences College of Nanjing Agricultural University, 1st Weigang, Nanjing, Jiangsu 210095, China 3.University of Chinese Academy of Sciences, Beijing 100009, China |
| 推荐引用方式 GB/T 7714 | Zhang ZY,Gao L,Shen CB,et al. A potent anti-thrombosis peptide (vasotab TY) from horsefly salivary glands[J]. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY,2014,54(X):83-88. |
| APA | Zhang ZY,Gao L,Shen CB,Rong MQ,Yan XW,&Lai R[*].(2014).A potent anti-thrombosis peptide (vasotab TY) from horsefly salivary glands.INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY,54(X),83-88. |
| MLA | Zhang ZY,et al."A potent anti-thrombosis peptide (vasotab TY) from horsefly salivary glands".INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY 54.X(2014):83-88. |
入库方式： OAI收割
来源：昆明动物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。