A Novel Neurotoxin from Venom of the Spider, Brachypelma albopilosum
文献类型：期刊论文
| 作者 | Zhong YH1,2; Song B3; Mo GX4; Yuan MW5; Li HL5; Wang P[*]1,2; Yuan ML[*]5; Lu QM[*]6 |
| 刊名 | PLOS ONE
 |
| 出版日期 | 2014 |
| 卷号 | 9期号:10页码:e110221 |
| 通讯作者 | 710205373@qq.com ; yml@188.com ; lvqm@mail.kiz.ac.cn |
| 合作状况 | 其它 |
| 英文摘要 | Spiders have evolved highly selective toxins for insects. There are many insecticidal neurotoxins in spider venoms. Although a large amount of work has been done to focus on neurotoxicity of spider components, little information, which is related with effects of spider toxins on tumor cell proliferation and cytotoxicity, is available for Brachypelma albopilosum venom. In this work, a novel spider neurotoxin (brachyin) was identified and characterized from venoms of the spider, Brachypelma albopilosum. Brachyin is composed of 41 amino acid residues with the sequence of CLGENVPCDKDRPNCCSRYECLEPT-GYGWWYASYYCYKKRS. There are six cysteines in this sequence, which form three disulfided bridges. The serine residue at the C-terminus is amidated. Brachyin showed strong lethal effects on American cockroaches (Periplaneta americana) and Tenebrio molitor (common mealbeetle). This neurotoxin also showed significant analgesic effects in mice models including abdominal writhing induced by acetic acid and formalin-induced paw licking tests. It was interesting that brachyin exerted marked inhibition on tumor cell proliferation. |
| 收录类别 | SCI |
| 资助信息 | This work was supported by the National Natural Science Foundation of China (31160198, 31360417), the Applied Basic Research Key Project of Yunnan (2013FA039), the Applied Basic Research Project of Yunnan (2011FB084), the High-End Technology Professionals Introduction Plan in Yunnan province (2010CI119). |
| 语种 | 英语 |
| WOS记录号 | WOS:000343942100043 |
| 公开日期 | 2014-12-05 |
| 源URL | [http://159.226.149.42:8088/handle/152453/8190]  |
| 专题 | 昆明动物研究所_动物毒素室 昆明动物研究所_动物模型与人类重大疾病机理重点实验室 |
| 作者单位 | 1.Faculty of Environmental Science and Engineering, Kunming University of Science and Technology, Kunming, Yunnan, China 2.Cadres Treatment Section & Thoracic Surgery Department, the First People’s Hospital of Yunnan Province, Kunming, Yunnan, China 3.School of Basic Medical Sciences, Yunnan University of Traditional Chinese Medicine, Kunming, Yunnan, China 4.College of Humanities & Social Sciences, Nanjing Agricultural University, Nanjing, Jiangsu, China 5.Engineering Research Center of Biopolymer Functional Materials of Yunnan, Yunnan University of Nationalities, Kunming, Yunnan, China 6.Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Kunming, Yunnan, China |
| 推荐引用方式 GB/T 7714 | Zhong YH,Song B,Mo GX,et al. A Novel Neurotoxin from Venom of the Spider, Brachypelma albopilosum[J]. PLOS ONE,2014,9(10):e110221. |
| APA | Zhong YH.,Song B.,Mo GX.,Yuan MW.,Li HL.,...&Lu QM[*].(2014).A Novel Neurotoxin from Venom of the Spider, Brachypelma albopilosum.PLOS ONE,9(10),e110221. |
| MLA | Zhong YH,et al."A Novel Neurotoxin from Venom of the Spider, Brachypelma albopilosum".PLOS ONE 9.10(2014):e110221. |
入库方式： OAI收割
来源：昆明动物研究所
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