YY-39, a tick anti-thrombosis peptide containing RGD domain
文献类型：期刊论文
| 作者 | Tang J1; Fang YQ1; Han YJ1; Bai XW1; Yan XW1; Zhang Y2; Lai R[*]1,2; Zhang ZY[*]2,3 |
| 刊名 | PEPTIDES
 |
| 出版日期 | 2015 |
| 卷号 | 68期号:X页码:99-104 |
| 关键词 | Tick Salivary gland Platelet inhibitor Anti thrombosis Glycoprotein |
| 通讯作者 | rlai@mail.kiz.ac.cn ; zhangzhiye5225@163.com |
| 合作状况 | 其它 |
| 英文摘要 | Ticks are obligatory blood feeding ectoparasites, which continuously attach to their hosts for 1-2 weeks. There are many biologically active compounds in tick salivary glands interfering host haemostatic system and to successfully obtain blood meal. Several platelet aggregation inhibitors have been identified from ticks. A family of conserved peptides, which were identified from transcriptome analysis of many tick salivary glands, were found to contain unique primary structure including predicted mature peptides of 39-47 amino acid residues in length and a Pro/Glu(P/E)-Pro/His(P/H)-Lys-Gly-Asp(RGD) domain. Given their unique structure and RGD domain, they are considered a novel family of disintegrins that inhibit platelet aggregation. One of them (YY-39) was tested for its effects on platelets and thrombosis in vivo. YY-39 was found effectively to inhibit platelet aggregation induced by adenosine diphosphate (ADP), thrombin and thromboxane A(2) (TXA2). Furthermore, YY-39 blocked platelet adhesion to soluble collagen and bound to purified GPIIb/IIIa in a dose-dependent manner. In in vivo experiments, YY-39 reduced thrombus weight effectively in a rat arteriovenous shunt model and inhibited thrombosis in a carrageenan-induced mouse tail thrombosis model. Combined with their prevalence in ticks and platelet inhibitory functions, this family of peptides might be conserved tick anti-haemostatic molecules |
| 收录类别 | SCI |
| 资助信息 | This work was supported by Ministry of Science and Technol- ogy (2010CB529800, 2013CB911300, 863 project 2012AA021801), National Natural Science Foundation (31025025, U1132601, U1302221,31200590,31260208),andCAS(KSZD-EW-Z-007,KJZD- EW-L03), Jiangsu Province (BK2012365, BE2012748). |
| 语种 | 英语 |
| 源URL | [http://159.226.149.26:8080/handle/152453/9397]  |
| 专题 | 昆明动物研究所_动物活性蛋白多肽组学 昆明动物研究所_动物模型与人类重大疾病机理重点实验室 昆明动物研究所_动物毒素室 |
| 作者单位 | 1.Life Sciences College of Nanjing Agricultural University, 1st Weigang, Nanjing, Jiangsu 210095, China 2.Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Kunming 650223, Yunnan, China 3.University of Chinese Academy of Sciences, Beijing 100009, China |
| 推荐引用方式 GB/T 7714 | Tang J,Fang YQ,Han YJ,et al. YY-39, a tick anti-thrombosis peptide containing RGD domain[J]. PEPTIDES,2015,68(X):99-104. |
| APA | Tang J.,Fang YQ.,Han YJ.,Bai XW.,Yan XW.,...&Zhang ZY[*].(2015).YY-39, a tick anti-thrombosis peptide containing RGD domain.PEPTIDES,68(X),99-104. |
| MLA | Tang J,et al."YY-39, a tick anti-thrombosis peptide containing RGD domain".PEPTIDES 68.X(2015):99-104. |
入库方式： OAI收割
来源：昆明动物研究所
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