Scorpion Toxin, BmP01, Induces Pain by Targeting TRPV1 Channel
文献类型：期刊论文
| 作者 | Hakim MA1,2; Jiang W3; Luo L1,2; Li BW1,2; Yang SL[*]1,2; Song YZ[*]3; Lai R[*]1,4 |
| 刊名 | TOXINS
 |
| 出版日期 | 2015 |
| 卷号 | 7期号:9页码:3671-3687 |
| 关键词 | BmP01 Kv channels TRPV1 pain peptide toxin scorpion Mesobuthus martensii |
| 通讯作者 | yslzoology@163.com ; yuzhusong@kmust.edu.cn ; rlai@mail.kiz.ac.cn |
| 合作状况 | 其它 |
| 英文摘要 | The intense pain induced by scorpion sting is a frequent clinical manifestation. To date, there is no established protocol with significant efficacy to alleviate the pain induced by scorpion envenomation. One of the important reasons is that, little information on pain-inducing compound from scorpion venoms is available. Here, a pain-inducing peptide (BmP01) has been identified and characterized from the venoms of scorpion (Mesobuthus martensii). In an animal model, intraplantar injection of BmP01 in mouse hind paw showed significant acute pain in wild type (WT) mice but not in TRPV1 knock-out (TRPV1 KO) mice during 30 min recording. BmP01 evoked currents in WT dorsal root ganglion (DRG) neurons but had no effect on DRG neurons of TRPV1 KO mice. Furthermore, BmP01 evoked currents on TRPV1-expressed HEK293T cells, but not on HEK293T cells without TRPV1. These results suggest that (1) BmP01 is one of the pain-inducing agents in scorpion venoms; and (2) BmP01 induces pain by acting on TRPV1. To our knowledge, this is the first report about a scorpion toxin that produces pain by targeting TRPV1. Identification of a pain-inducing compound may facilitate treating pain induced by scorpion envenomation. |
| 收录类别 | SCI |
| 资助信息 | This work was supported by funding from Ministry of Science and Technology of China (2013CB911300, 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601, 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L. |
| 语种 | 英语 |
| 源URL | [http://159.226.149.26:8080/handle/152453/9427]  |
| 专题 | 昆明动物研究所_动物毒素室 昆明动物研究所_动物模型与人类重大疾病机理重点实验室 |
| 作者单位 | 1.Key Laboratory of Animal Models and Human Disease Mechanisms, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China 2.Graduate University of Chinese Academy of Sciences, Beijing 100049, China 3.Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming 650223, China 4.Joint Laboratory of Natural Peptide, University of Science and Technology of China and Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China |
| 推荐引用方式 GB/T 7714 | Hakim MA,Jiang W,Luo L,et al. Scorpion Toxin, BmP01, Induces Pain by Targeting TRPV1 Channel[J]. TOXINS,2015,7(9):3671-3687. |
| APA | Hakim MA.,Jiang W.,Luo L.,Li BW.,Yang SL[*].,...&Lai R[*].(2015).Scorpion Toxin, BmP01, Induces Pain by Targeting TRPV1 Channel.TOXINS,7(9),3671-3687. |
| MLA | Hakim MA,et al."Scorpion Toxin, BmP01, Induces Pain by Targeting TRPV1 Channel".TOXINS 7.9(2015):3671-3687. |
入库方式： OAI收割
来源：昆明动物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。