An immunoregulatory peptide from tsetse fly salivary glands of Glossina morsitans morsitans
文献类型：期刊论文
| 作者 | Bai XW1; Yao HM1; Du CW1; Chen Y1; Lai R[*]1; Rong MQ[*]2 |
| 刊名 | BIOCHIMIE
 |
| 出版日期 | 2015 |
| 卷号 | 118期号:X页码:123–128 |
| 关键词 | Immunosuppressant peptide Salivary gland Tsetse fly |
| 通讯作者 | rlai72@njau.edu.cn ; rongmingqiang@mail.kiz.ac.cn |
| 合作状况 | 其它 |
| 英文摘要 | Tsetse fly Glossina morsitans morsitans is an important insect vector of African trypanosomes, which cause human African trypanosomiasis (HAT). As other hematophagous arthropods, tsetse fly relies heavily on the pharmacological propriety of their saliva to suppress host's immune reactions and get blood meal. However little information is available on immune regulators from testes fly. An immunoregulatory peptide named Gloss 2 containing amino acid sequence of QKNDTAFSCHFFEIYL SNCFNKE-KYIKNYLQIM has been identified from salivary glands of the tsetse fly of G. morsitans morsitans (Diptera: Glossinidae). Gloss 2 has the ability to inhibit the secretion of tumor necrosis factor-alpha (TNF-alpha), interferon-gamma (IFN-gamma),interleukin-6 (IL-6) and interleukin-10 (IL-10) induced by lipopolysaccharide (LPS) in mouse splenocytes. Besides, Gloss 2 significantly suppressed the LPS-induced activation of MAPK signaling pathway through blocking phosphorylations of JNK, Erk and P38. Gloss 2 probably inhibits host inflammatory responses by inhibiting secretion of TNF-alpha, IFN-gamma and IL-6. Considering IL-10's ability to promote humoral immune responses by enhancing class II expression B cells and inducing immunoglobulin (Ig) production, Gloss 2 may inhibit host humoral immune response by inhibiting IL-10 secretion. The immune-suppression may facilitate the blood feeding of tsetse fly and transmission of African trypanosomes to hosts. (C) 2015 Elsevier B.V. and Societe Francaise de Biochimie et Biologie Moleculaire (SFBBM). |
| 收录类别 | SCI |
| 资助信息 | This work was supported by MOST (2013CB911300, 2010CB529800), NSFC (31025025, 31260208, U1132601, X. Bai et al. / Biochimie 118 (2015) 123e128 127 31200590), CAS (SAJC201308, Y302B01021) and Yunnan Province (2011CI139, 2012BC009), the West light Doctoral program and Youth Innovation Promotion Association of CAS. |
| 语种 | 英语 |
| 源URL | [http://159.226.149.26:8080/handle/152453/9445]  |
| 专题 | 昆明动物研究所_动物毒素室 昆明动物研究所_动物模型与人类重大疾病机理重点实验室 |
| 作者单位 | 1.Life Sciences College of Nanjing Agricultural University, Nanjing 210095, Jiangsu, China 2.Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Kunming 650223, Yunnan, China |
| 推荐引用方式 GB/T 7714 | Bai XW,Yao HM,Du CW,et al. An immunoregulatory peptide from tsetse fly salivary glands of Glossina morsitans morsitans[J]. BIOCHIMIE,2015,118(X):123–128. |
| APA | Bai XW,Yao HM,Du CW,Chen Y,Lai R[*],&Rong MQ[*].(2015).An immunoregulatory peptide from tsetse fly salivary glands of Glossina morsitans morsitans.BIOCHIMIE,118(X),123–128. |
| MLA | Bai XW,et al."An immunoregulatory peptide from tsetse fly salivary glands of Glossina morsitans morsitans".BIOCHIMIE 118.X(2015):123–128. |
入库方式： OAI收割
来源：昆明动物研究所
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