Centipede Venoms and Their Components: Resources for Potential Therapeutic Applications
文献类型：期刊论文
| 作者 | Hakim MA1,2; Yang S1,2; Lai R[*]1,3 |
| 刊名 | TOXINS
 |
| 出版日期 | 2015 |
| 卷号 | 7期号:11页码:4832-4851 |
| 关键词 | centipedes peptides pharmacology therapeutics toxins venom |
| 通讯作者 | rlai@mail.kiz.ac.cn |
| 英文摘要 | Venomous animals have evolved with sophisticated bio-chemical strategies to arrest prey and defend themselves from natural predators. In recent years, peptide toxins from venomous animals have drawn considerable attention from researchers due to their surprising chemical, biochemical, and pharmacological diversity. Similar to other venomous animals, centipedes are one of the crucial venomous arthropods that have been used in traditional medicine for hundreds of years in China. Despite signifying pharmacological importance, very little is known about the active components of centipede venoms. More than 500 peptide sequences have been reported in centipede venomous glands by transcriptome analysis, but only a small number of peptide toxins from centipede has been functionally described. Like other venomous animals such as snakes, scorpions, and spiders, the venom of centipedes could be an excellent source of peptides for developing drugs for treatments as well as bio-insecticides for agrochemical applications. Although centipede venoms are yet to be adequately studied, the venom of centipedes as well as their components described to date, should be compiled to help further research. Therefore, based on previous reports, this review focusses on findings and possible therapeutic applications of centipede venoms as well as their components. |
| 收录类别 | SCI |
| 资助信息 | We acknowledge the financial support from the Ministry of Science and Technology of China (2013CB911300, 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601, 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to Ren Lai. |
| 语种 | 英语 |
| 源URL | [http://159.226.149.26:8080/handle/152453/9494]  |
| 专题 | 昆明动物研究所_动物毒素室 昆明动物研究所_动物模型与人类重大疾病机理重点实验室 |
| 作者单位 | 1.Key Laboratory of Animal Models and Human Disease Mechanisms, Kunming Institute of Zoology, Chinese Academy of sciences, Kunming 650223, Yunnan, China 2.University of Chinese Academy of Sciences, Beijing100009, China 3.Joint Laboratory of Natural Peptide, University of Science and Technology of China and Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China |
| 推荐引用方式 GB/T 7714 | Hakim MA,Yang S,Lai R[*]. Centipede Venoms and Their Components: Resources for Potential Therapeutic Applications[J]. TOXINS,2015,7(11):4832-4851. |
| APA | Hakim MA,Yang S,&Lai R[*].(2015).Centipede Venoms and Their Components: Resources for Potential Therapeutic Applications.TOXINS,7(11),4832-4851. |
| MLA | Hakim MA,et al."Centipede Venoms and Their Components: Resources for Potential Therapeutic Applications".TOXINS 7.11(2015):4832-4851. |
入库方式： OAI收割
来源：昆明动物研究所
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