Mitochondrial DNA-LL-37 Complex Promotes Atherosclerosis by Escaping from Autophagic Recognition
文献类型：期刊论文
| 作者 | Zhang ZY1,3; Meng P2; Han YJ2; Shen CB1,3; Li BW1,3; Hakim MA1,3; Zhang XG4; Lu QM1; Rong MQ1; Lai R[*]1,2 |
| 刊名 | IMMUNITY
 |
| 出版日期 | 2015 |
| 卷号 | 43期号:6页码:1137-1147 |
| 通讯作者 | rlai@mail.kiz.ac.cn |
| 合作状况 | 其它 |
| 英文摘要 | Atherosclerosis is a chronic inflammatory disease of arterial wall. Mitochondrial DNA (mtDNA) and human antimicrobial peptide LL-37 (Cramp in mice) are involved in atherosclerosis. Recently, mtDNA has been found to escape from autophagy and cause inflammation. Normally, mtDNA as an inflammatogenic factor cannot escape from autophagy and degradation by DNase II. In this study, we found elevated amounts of LL37-mtDNA complex in atherosclerotic plasma and plaques. The complex was resistant to DNase II degradation and escaped from autophagic recognition, leading to activation of Toll-like receptor 9 (TLR9)-mediated inflammatory responses. Mouse model studies indicated that Cramp-mtDNA complex aggravated atherosclerotic lesion formation in apolipoprotein E-deficient mice and antibody treatment against the complex alleviated the lesion. These findings suggest that the LL-37-mtDNA complex acts as a key mediator of atherosclerosis formation, and thus represents a promising therapeutic target. |
| 收录类别 | SCI |
| 资助信息 | This work was supported by MOST (2013CB911300), NSFC (U1132601, 31200590), CAS (XDB13000000, KSZD-EW-Z-007, XDA12040209), and Yunnan Province (2012BC009). |
| 语种 | 英语 |
| 源URL | [http://159.226.149.26:8080/handle/152453/9511]  |
| 专题 | 昆明动物研究所_动物毒素室 昆明动物研究所_动物模型与人类重大疾病机理重点实验室 |
| 作者单位 | 1.Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Kunming 650223, Yunnan, China 2.Life Sciences College of Nanjing Agricultural University, 1st Weigang, Nanjing 210095, Jiangsu, China 3.University of Chinese Academy of Sciences, Beijing 100009, China 4.Major Cardiovascular Surgery, Kunming Yanan Hospital, Kunming 650051, Yunnan, China |
| 推荐引用方式 GB/T 7714 | Zhang ZY,Meng P,Han YJ,et al. Mitochondrial DNA-LL-37 Complex Promotes Atherosclerosis by Escaping from Autophagic Recognition[J]. IMMUNITY,2015,43(6):1137-1147. |
| APA | Zhang ZY.,Meng P.,Han YJ.,Shen CB.,Li BW.,...&Lai R[*].(2015).Mitochondrial DNA-LL-37 Complex Promotes Atherosclerosis by Escaping from Autophagic Recognition.IMMUNITY,43(6),1137-1147. |
| MLA | Zhang ZY,et al."Mitochondrial DNA-LL-37 Complex Promotes Atherosclerosis by Escaping from Autophagic Recognition".IMMUNITY 43.6(2015):1137-1147. |
入库方式： OAI收割
来源：昆明动物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。