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α-Neurotoxins of Naja atra and Naja kaouthia Snakes in Different Regions

文献类型：期刊论文

作者Wei JF1,2; Lu QM1; Wang WY1; Jin Y1; Li DS1; Xiong YL[*]1
刊名ACTA BIOCHIMICA ET BIOPHYSICA SINICA
出版日期2003
卷号35期号:8页码:683-688
关键词Naja kaouthia Naja atra alpha-neurotoxins prey
其他题名不同地区舟山种和孟加拉种眼镜蛇的神经毒素
通讯作者wangwy@mail.kiz.ac.cn
合作状况其它
中文摘要先前的工作发现 ,眼镜蛇孟加拉种的神经毒分布存在明显的地理差异 ,但是导致这种现象的原因还不是很清楚。该工作首先采集夏季的眼镜蛇种 ,进行分类学的鉴定 ,以排除因为种属分类、季节和年龄而导致的不确定因素对蛇毒成分产生影响。再从鉴定好的成年浙江舟山种和云南孟加拉种眼镜蛇蛇毒中分离获得短链神经毒素 ;同时采用RT PCR方法得到相应的基因。结果从浙江舟山种眼镜蛇蛇毒中分离到两个神经毒素 ;从云南孟加拉种蛇毒中得到三个神经毒素。这些神经毒素都是短链神经毒素。说明该两个蛇种与已经报道的台湾及浙江的舟山种眼镜蛇很相似 ,蛇毒中都以短链神经毒素为主。另外泰国孟加拉种眼镜蛇蛇毒中则以长链神经毒素为主。这种现象很难用种群发生的前后或者地理距离的长短来解释 ,而可能与地区间的气候、地理环境或者眼镜蛇的食物差别相关。实验统计表明在云南、浙江和台湾这些条件基本相似 ,而泰国就有很大的不同。 
英文摘要Recent studies have shown that there are geographic variation of alpha-neurotoxins in Naja kaouthia, but the cause is not clear yet. In this work, venoms were collected from adult Naja atra in Zhejiang Province and Naja kaouthia in Yunnan Province, well identified by morphological characters and cytochrome b gene analysis in summer season to avoid age and seasonal variation in the venom composition. Then alpha-neurotoxins were purified and cloned from these two kinds of snakes. Three alpha-neurotoxins from Naja kaouthia (Yunnan) and two from Naja atra (Zhejiang) were identified. Together with previously reported alpha-neurotoxins in Naja kaouthia (Thailand) and Naja atra (Taiwan Province), it was found that the alpha-neurotoxins of Naja kaouthia in Yunnan Province were similar to those of Naja atra in Zhejiang and Taiwan Provinces, but different from those of Naja kaouthia in Thailand. This result can hardly be explained by population phylogeny or geographic distance. It might be due to the different climate, habitat and prey in Thailand in comparison with those in Yunnan, Zhejiang and Taiwan Provinces.
收录类别SCI
资助信息国家自然科学基金资助项目 (No.39670165)
语种英语
源URL[http://159.226.149.26:8080/handle/152453/9775]  
专题昆明动物研究所_动物毒素室
昆明动物研究所_其他
作者单位1.Chinese Acad Sci, Kunming Inst Zool, Dept Anim Toxicol, Kunming 650223, Peoples R China
2.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China
推荐引用方式
GB/T 7714		 Wei JF,Lu QM,Wang WY,et al. α-Neurotoxins of Naja atra and Naja kaouthia Snakes in Different Regions[J]. ACTA BIOCHIMICA ET BIOPHYSICA SINICA,2003,35(8):683-688.
APA Wei JF,Lu QM,Wang WY,Jin Y,Li DS,&Xiong YL[*].(2003).α-Neurotoxins of Naja atra and Naja kaouthia Snakes in Different Regions.ACTA BIOCHIMICA ET BIOPHYSICA SINICA,35(8),683-688.
MLA Wei JF,et al."α-Neurotoxins of Naja atra and Naja kaouthia Snakes in Different Regions".ACTA BIOCHIMICA ET BIOPHYSICA SINICA 35.8(2003):683-688.

入库方式： OAI收割

来源：昆明动物研究所

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