A Designed Tryptophan- and Lysine/Arginine-Rich Antimicrobial Peptide with Therapeutic Potential for Clinical Antibiotic-Resistant Candida albicans Vaginitis
文献类型：期刊论文
| 作者 | Jin L1; Bai XW1; Luan N1; Yao HM1; Zhang ZY2,3; Liu WH1; Chen Y1; Yan XW1; Rong MQ2,3; Lai R[*]2,3 |
| 刊名 | JOURNAL OF MEDICINAL CHEMISTRY
 |
| 出版日期 | 2016 |
| 卷号 | 59期号:5页码:1791-1799 |
| 通讯作者 | rlai72@njau.edu.cn ; luqiumin@aliyun.com |
| 合作状况 | 其它 |
| 英文摘要 | New therapeutic agents for Candida albicans vaginitis are urgently awaiting to be developed because of the increasing antibiotic resistance of C. albicans. Antimicrobial peptides (AMPs) are one of the most promising choices for next-generation antibiotics. In this study, novel peptides were designed based on snake venom antimicrobial peptide cathelicidin-BF to promote anti-C. albicans activity and decrease side-effects. The designing strategies include substitutions of charged or hydrophobic amino acid residues for noncharged polar residues to promote antimicrobial activity and insertion of a hydrophobic residue in the hydrophilic side of the helix structure to reduce hemolysis. A designed tryptophan and lysine/arginine-rich cationic peptide 4 (ZY13) (VKRWKKWRWKWKKWV-NH2) exhibited excellent antimicrobial activity against either common strain or clinical isolates of antibiotic-resistant C. albicans with little hemolysis. Peptide 4 showed significant therapeutic effects on vaginitis in mice induced by the infection of clinical antibiotic-resistant C. albicans. The approaches herein might be useful for designing of AMPs. |
| 收录类别 | SCI |
| 资助信息 | This work was supported by the Ministry of Science and Technology (2013CB911300), Chinese National Natural Science Foundation (31025025, 31260208, U1132601, 31200590), Chinese Academy of Sciences (SAJC201308, Y302B01021), and Yunnan Provincial Science and Technology Department (2011CI139, 2012BC009). |
| 语种 | 英语 |
| 源URL | [http://159.226.149.26:8080/handle/152453/10235]  |
| 专题 | 昆明动物研究所_动物毒素室 昆明动物研究所_动物模型与人类重大疾病机理重点实验室 |
| 作者单位 | 1.Life Sciences College of Nanjing Agricultural University, Nanjing 210095, Jiangsu, China 2.Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Kunming 650223, Yunnan, China 3.Joint Laboratory of Natural Peptide of University of Science and Technology of China and Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, Yunnan, China |
| 推荐引用方式 GB/T 7714 | Jin L,Bai XW,Luan N,et al. A Designed Tryptophan- and Lysine/Arginine-Rich Antimicrobial Peptide with Therapeutic Potential for Clinical Antibiotic-Resistant Candida albicans Vaginitis[J]. JOURNAL OF MEDICINAL CHEMISTRY,2016,59(5):1791-1799. |
| APA | Jin L.,Bai XW.,Luan N.,Yao HM.,Zhang ZY.,...&Lu QM[*].(2016).A Designed Tryptophan- and Lysine/Arginine-Rich Antimicrobial Peptide with Therapeutic Potential for Clinical Antibiotic-Resistant Candida albicans Vaginitis.JOURNAL OF MEDICINAL CHEMISTRY,59(5),1791-1799. |
| MLA | Jin L,et al."A Designed Tryptophan- and Lysine/Arginine-Rich Antimicrobial Peptide with Therapeutic Potential for Clinical Antibiotic-Resistant Candida albicans Vaginitis".JOURNAL OF MEDICINAL CHEMISTRY 59.5(2016):1791-1799. |
入库方式： OAI收割
来源：昆明动物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。