Curcumin shows excellent therapeutic effect on psoriasis in mouse model
文献类型：期刊论文
| 作者 | Kang D1,2; Li BW1,2; Rong MQ[*]1; Lai R[*]1; Luo L1,2; Jiang WB3; Lu QM1 |
| 刊名 | BIOCHIMIE
 |
| 出版日期 | 2016 |
| 卷号 | 123期号:X页码:73-80 |
| 关键词 | Curcumin Kv1.3 channel Cytokine Psoriasis |
| 通讯作者 | rongmingqiang@mail.kiz.ac.cn ; rlai@mail.kiz.ac.cn |
| 中文摘要 | Curcumin is an active herbal ingredient possessing surprisingly wide range of beneficial properties, including anti-inflammatory, antioxidant, chemopreventive and chemotherapeutic activity. Recently, it has been reported to exhibit inhibitory activity on potassium channel subtype Kv1.3. As Kv1.3 channels are mainly expressed in T cells and play a key role in psoriasis, the effects of curcumin were investigated on inflammatory factors secretion in T cells and psoriasis developed in keratin (K) 14-vascular endothelial growth factor (VEGF) transgenic mouse model. Results showed that, 10 mu M of curcumin significantly inhibited secretion of inflammatory factors including interleukin (IL)-17,IL-22, IFN-gamma, IL-2, IL-8 and TNF-alpha in T cells by 30-60% in vitro. Notably, more than 50% of T cells proliferation was inhibited by application of 100 mu M curcumin. Compared with severe psoriatic symptoms observed in the negative control mice, all psoriasis indexes including ear redness, weight, thickness and lymph node weight were significantly improved by oral application of curcumin in treatment mouse group. Histological examination indicated that curcumin had anti-inflammatory function in the experimental animals. More than 50% level of inflammatory factors including TNF-alpha, IFN-gamma, IL-2, IL-12, IL-22 and IL-23 in mouse serum was decreased by curcumin treatment as well as cyclosporine. Compared with renal fibrosis observed in the mouse group treated by cyclosporine, no obvious side effect in mouse kidney was found after treated by cur-cumin. Taken together, curcumin, with high efficacy and safety, has a great potential to treat psoriasis. |
| 收录类别 | SCI |
| 资助信息 | This work was supported by MOST (2013CB911300, 2010CB5 29800), NSFC (31025025, 31025025, U1132601, 31200590), the West light Doctoral program and Youth Innovation Promotion As- sociation of CAS and Yunan Province (2013FB072). |
| 语种 | 英语 |
| 源URL | [http://159.226.149.26:8080/handle/152453/10304]  |
| 专题 | 昆明动物研究所_动物毒素室 昆明动物研究所_动物模型与人类重大疾病机理重点实验室 |
| 作者单位 | 1.Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Kunming 650223, Yunnan, China 2.University of Chinese Academy of Sciences, Beijing 100009, China 3.College of Life Science and Technology, Kunming University of Science and Technology, China |
| 推荐引用方式 GB/T 7714 | Kang D,Li BW,Rong MQ[*],et al. Curcumin shows excellent therapeutic effect on psoriasis in mouse model[J]. BIOCHIMIE,2016,123(X):73-80. |
| APA | Kang D.,Li BW.,Rong MQ[*].,Lai R[*].,Luo L.,...&Lu QM.(2016).Curcumin shows excellent therapeutic effect on psoriasis in mouse model.BIOCHIMIE,123(X),73-80. |
| MLA | Kang D,et al."Curcumin shows excellent therapeutic effect on psoriasis in mouse model".BIOCHIMIE 123.X(2016):73-80. |
入库方式： OAI收割
来源：昆明动物研究所
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