Frog skins keep redox homeostasis by antioxidant peptides with rapid radical scavenging ability
文献类型：期刊论文
| 作者 | Liu CB1,2; Hong J2,3; Li DS1; Lin DH[*]3; Lai R[*]1,4; Yang HL1,2; Wu J1,2; Ma DY1,2 |
| 刊名 | FREE RADICAL BIOLOGY AND MEDICINE
 |
| 出版日期 | 2010 |
| 卷号 | 48期号:9页码:1173-1181 |
| 关键词 | Radical scavenging peptide Amphibian skin Redox homeostasis Free radicals |
| 通讯作者 | dhlin@mail.shcnc.ac.cn ; rlai@mail.kiz.ac.cn |
| 合作状况 | 其它 |
| 英文摘要 | The question of how amphibians can protect themselves from reactive oxygen species when exposed to the sun in an oxygen-rich atmosphere is important and interesting, not only from an evolutionary viewpoint, but also as a primer for researchers interested in mammalian skin biology, in which such peptide systems for antioxidant defense are not well studied. The identification of an antioxidant peptide named antioxidin-RL from frog (Odorrana livida) skin in this report supports the idea that a peptide antioxidant system may be a widespread antioxidant strategy among amphibian skins. Its ability to eliminate most of the 2,2'-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) radical tested within 2 s, which is much faster than the commercial antioxidant factor butylated hydroxytoluene, suggests that it has a potentially large impact on redox homeostasis in amphibian skins. Cys10 is proven to be responsible for its rapid radical scavenging function and tyrosines take part in the binding of antioxidin-RL to radicals according to our nuclear magnetic resonance assay. |
| 收录类别 | SCI |
| 资助信息 | This work was supported by the Chinese National Natural Science Foundation (30830021), Chinese Academy of Sciences (KSCX2-YW- G-024), and Ministry of Science (2008AA02Z133, 2010CB529801/05) and by Yunnan Province (0803461101). |
| 语种 | 英语 |
| 源URL | [http://159.226.149.26:8080/handle/152453/10459]  |
| 专题 | 昆明动物研究所_动物毒素室 昆明动物研究所_动物模型与人类重大疾病机理重点实验室 |
| 作者单位 | 1.Biotoxin Unit of the Key Laboratory of Animal Models and Human Disease Mechanisms, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, Yunnan, China 2.Graduate School, Chinese Academy of Sciences, Beijing, China 3.Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China 4.Key Laboratory of Microbiological Engineering of the Agricultural Environment, Ministry of Agriculture, Life Sciences College, Nanjing Agricultural University, Nanjing, Jiangsu, China |
| 推荐引用方式 GB/T 7714 | Liu CB,Hong J,Li DS,et al. Frog skins keep redox homeostasis by antioxidant peptides with rapid radical scavenging ability[J]. FREE RADICAL BIOLOGY AND MEDICINE,2010,48(9):1173-1181. |
| APA | Liu CB.,Hong J.,Li DS.,Lin DH[*].,Lai R[*].,...&Ma DY.(2010).Frog skins keep redox homeostasis by antioxidant peptides with rapid radical scavenging ability.FREE RADICAL BIOLOGY AND MEDICINE,48(9),1173-1181. |
| MLA | Liu CB,et al."Frog skins keep redox homeostasis by antioxidant peptides with rapid radical scavenging ability".FREE RADICAL BIOLOGY AND MEDICINE 48.9(2010):1173-1181. |
入库方式： OAI收割
来源：昆明动物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。