Peptidomics and genomics analysis of novel antimicrobial peptides from the frog, Rana nigrovittata
文献类型：期刊论文
| 作者 | Ma YF1,4; Liu CB1,4; Wang YP1,4; Li JX1; Yu HN[*]3; Lai R[*]1,2; Liu XH2; Wu J1,4; Yang HL1,4 |
| 刊名 | GENOMICS
 |
| 出版日期 | 2010 |
| 卷号 | 95期号:1页码:66-71 |
| 关键词 | Peptidomics Genomics Amphibian Antimicrobial peptides (AMPs) cDNA Rana nigrovittata |
| 通讯作者 | yuhaining@mail.hebtu.edu.cn ; rlai@mail.kiz.ac.cn |
| 合作状况 | 其它 |
| 英文摘要 | Much attention has been paid on amphibian peptides for their wide-ranging pharmacological properties, clinical potential, and gene-encoded origin. More than 300 antimicrobial peptides (AMPs) from amphibians have been studied. Peptidomics and genomics analysis combined with functional test including microorganism killing, histamine-releasing, and mast cell degranulation was used to investigate antimicrobial peptide diversity. Thirty-four novel AMPs from skin secretions of Rana nigrovittata were identified in current work, and they belong to 9 families, including 6 novel families. Other three families are classified into rugosin, gaegurin, and temporin family of amphibian AMP, respectively. These AMPs share highly conserved preproregions including signal peptides and spacer acidic peptides, while greatly diversified on mature peptides structures. In this work, peptidomics combined with genomics analysis was confirmed to be an effective way to identify amphibian AMPs, especially novel families. Some AMPs reported here will provide leading molecules for designing novel antimicrobial agents. |
| 收录类别 | SCI |
| 资助信息 | This work was supported by the Chinese National Natural Science Foundation (30830021), Chinese Academy of Sciences (KSCXZ-YW-R- 088, KSCX2-YW-G-024), and the Ministry of Science (2007AA02Z192, 2007AA100602). |
| 语种 | 英语 |
| 源URL | [http://159.226.149.26:8080/handle/152453/10470]  |
| 专题 | 昆明动物研究所_动物毒素室 昆明动物研究所_动物模型与人类重大疾病机理重点实验室 |
| 作者单位 | 1.Biotoxin Units of Key Laboratory of Animal Models and Human Disease Mechanisms, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, Yunnan, China 2.Life Sciences College of Nanjing Agricultural University, Nanjing 210095, Jiangsu, China 3.College of Life Sciences, Hebei Normal University, Shijiazhuang 050016, Hebei, China 4.Graduate School of the Chinese Academy of Sciences, Beijing 100009, China |
| 推荐引用方式 GB/T 7714 | Ma YF,Liu CB,Wang YP,et al. Peptidomics and genomics analysis of novel antimicrobial peptides from the frog, Rana nigrovittata[J]. GENOMICS,2010,95(1):66-71. |
| APA | Ma YF.,Liu CB.,Wang YP.,Li JX.,Yu HN[*].,...&Yang HL.(2010).Peptidomics and genomics analysis of novel antimicrobial peptides from the frog, Rana nigrovittata.GENOMICS,95(1),66-71. |
| MLA | Ma YF,et al."Peptidomics and genomics analysis of novel antimicrobial peptides from the frog, Rana nigrovittata".GENOMICS 95.1(2010):66-71. |
入库方式： OAI收割
来源：昆明动物研究所
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