Phenolic acids isolated from the fungus Schizophyllum commune exert analgesic activity by inhibiting voltage-gated sodium channels
文献类型：期刊论文
| 作者 | Yao HM1; Wang G1; Yan XW1; Luo XD[*]3; Lai R[*]1,2; Liu YP3; Rong MQ2; Shen CB2 |
| 刊名 | CHINESE JOURNAL OF NATURAL MEDICINES
 |
| 出版日期 | 2016 |
| 卷号 | 14期号:9页码:661−670 |
| 关键词 | Pain Phenolic acids Schizophyllum commune Sodium channel |
| 通讯作者 | rlai72@njau.edu.cn ; xdluo@mail.kib.ac.cn |
| 英文摘要 | The present study was designed to search for compounds with analgesic activity from the Schizophyllum commune (SC), which is widely consumed as edible and medicinal mushroom world. Thin layer chromatography (TLC), tosilica gel column chromatography, sephadex LH 20, and reverse-phase high performance liquid chromatography (RP-HPLC) were used to isolate and purify compounds from SC. Structural analysis of the isolated compounds was based on nuclear magnetic resonance (NMR). The effects of these compounds on voltage-gated sodium (NaV) channels were evaluated using patch clamp. The analgesic activity of these compounds was tested in two types of mouse pain models induced by noxious chemicals. Five phenolic acids identified from SC extracts in the present study included vanillic acid, m-hydroxybenzoic acid, o-hydroxybenzeneacetic acid, 3-hydroxy-5-methybenzoic acid, and p-hydroxybenzoic acid. They inhibited the activity of both tetrodotoxin-resistant (TTX-r) and tetrodotoxin-sensitive (TTX-s) NaV channels. All the compounds showed low selectivity on NaV channel subtypes. After intraperitoneal injection, three compounds of these compounds exerted analgesic activity in mice. In conclusion, phenolic acids identified in SC demonstrated analgesic activity, facilitating the mechanistic studies of SC in the treatment of neurasthenia. |
| 收录类别 | SCI |
| 资助信息 | This work was partly supported by Ministry of Science and Technology of China (No. 2013CB911300), National Natural Science Foundation of China (Nos. 81225024, 31025025, 31260208, and U1132601). |
| 语种 | 英语 |
| 源URL | [http://159.226.149.26:8080/handle/152453/10502]  |
| 专题 | 昆明动物研究所_动物毒素室 昆明动物研究所_动物模型与人类重大疾病机理重点实验室 |
| 作者单位 | 1.College of Life Sciences Nanjing Agricultural University, Nanjing 210095, China 2.Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Kunming 650223, China 3.State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences , Kunming 650204, China |
| 推荐引用方式 GB/T 7714 | Yao HM,Wang G,Yan XW,et al. Phenolic acids isolated from the fungus Schizophyllum commune exert analgesic activity by inhibiting voltage-gated sodium channels[J]. CHINESE JOURNAL OF NATURAL MEDICINES,2016,14(9):661−670. |
| APA | Yao HM.,Wang G.,Yan XW.,Luo XD[*].,Lai R[*].,...&Shen CB.(2016).Phenolic acids isolated from the fungus Schizophyllum commune exert analgesic activity by inhibiting voltage-gated sodium channels.CHINESE JOURNAL OF NATURAL MEDICINES,14(9),661−670. |
| MLA | Yao HM,et al."Phenolic acids isolated from the fungus Schizophyllum commune exert analgesic activity by inhibiting voltage-gated sodium channels".CHINESE JOURNAL OF NATURAL MEDICINES 14.9(2016):661−670. |
入库方式： OAI收割
来源：昆明动物研究所
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