Prokineticin 2 Plays a Pivotal Role in Psoriasis
文献类型：期刊论文
| 作者 | He XQ1; Shen CB1,2; He L4; Bei RZ5; Zheng J6; Luan N7; Zhang ZY1; Rong MQ[*]1; Lu QM1; Lai R[*]1 |
| 刊名 | EBioMedicine
 |
| 出版日期 | 2016 |
| 卷号 | 13期号:X页码:248-261 |
| 关键词 | Angiogenesis Cell proliferation Inflammation Interleukin-1 Prokineticin2 Psoriasis |
| 通讯作者 | rongmingqiang@mail.kiz.ac.cn ; rlai@mail.kiz.ac.cn |
| 英文摘要 | Psoriasis is histologically characterized by keratinocytes (KC) hyperproliferation, inflammation, and increased angiogenesis, but the pathological factor responsible for these symptoms is unknown. Here, a neuroendocrine peptide (prokineticin 2, PK2), is highly expressed in human and mouse psoriatic skins but no significant change in other autoimmune diseases, suggesting that PK2 is a psoriasis-specific factor. Bacterial products significantly up-regulated PK2, implying that infection induces PK2 over-expression. PK2 promoted KC and macrophage to produce interleukin-1 (IL-1), the central player of inflammation and psoriasis, which acts on adjacent fibroblast to induce inflammatory cascades and KC hyperproliferation. IL-1 feeds back on macrophages to induce PK2 production to perpetuate PK2-IL-1 positive feedback loop. PK2 also promoted angiogenesis, another psoriatic symptom. In mouse models, PK2 over-expression aggravated psoriasis while its knock-down inhibited pathological development. The results indicate that PK2 over-production perpetuates psoriatic symptoms by creating PK-2-IL-1 vicious loop. PK2 is a central player in psoriasis and a promising psoriasis-specific target. |
| 资助信息 | This work was supported by funding from MOST (2013CB911300), NSFC (U1132601, 31200590), CAS (XDB13000000, XDA12020334, KSZD-EW-Z-007) and Yunnan Province (2012BC009). |
| 收录类别 | SCI |
| 语种 | 英语 |
| 源URL | [http://159.226.149.26:8080/handle/152453/10676]  |
| 专题 | 昆明动物研究所_动物毒素室 昆明动物研究所_动物模型与人类重大疾病机理重点实验室 |
| 作者单位 | 1.Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences/Key Laboratory of Bioactive Peptides of Yunnan Province, Kunming Institute of Zoology, Kun- ming 650223, Yunnan, China 2.University of Chinese Academy of Sciences, Beijing 100009, China 3.State Key Laboratory of Biotherapy, Cancer Center, West China Hospital, Sichuan University, Chengdu 610041, China 4.The Department of dermatology, The First Affiliated Hospital of Kunming Medical University, Kunming 650032, Yunnan, China 5.The Department of Pathology, The Affiliated Hospital of Jiangnan University Wuxi 4th People's Hospital, Wuxi 214062, Jiangsu, China 6.Department of Physiology and Membrane Biology, University of California, Davis, California 95616, United States 7.Life Sciences College of Nanjing Agricultural University, Nanjing 210095, Jiangsu, China |
| 推荐引用方式 GB/T 7714 | He XQ,Shen CB,He L,et al. Prokineticin 2 Plays a Pivotal Role in Psoriasis[J]. EBioMedicine,2016,13(X):248-261. |
| APA | He XQ.,Shen CB.,He L.,Bei RZ.,Zheng J.,...&Wei YQ.(2016).Prokineticin 2 Plays a Pivotal Role in Psoriasis.EBioMedicine,13(X),248-261. |
| MLA | He XQ,et al."Prokineticin 2 Plays a Pivotal Role in Psoriasis".EBioMedicine 13.X(2016):248-261. |
入库方式： OAI收割
来源：昆明动物研究所
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