Two antimicrobial peptides from skin secretions of Rana grahami
文献类型：期刊论文
| 作者 | Xu XQ1,3; Li JX1,3; Lu QM1; Lai R[*]1,2; Han YP1,4; Yang HL1; Liang JG2 |
| 刊名 | TOXICON
 |
| 出版日期 | 2006 |
| 卷号 | 47期号:4页码:459-464 |
| 关键词 | amphibian antimicrobial peptide grahamin Rana grahami skin |
| 通讯作者 | rlai@mail.kiz.ac.cn |
| 英文摘要 | Two antimicrobial peptides manifested a broad spectrum of anti microbial activity against various microorganisms have been isolated from skin secretions of Rana grahami. These antimicrobial peptides were named grahamin 1 and grahamin 2. Their primary Structures are GLLSGILGAGKNIVCGLSGLC and GLLSGILGAGKHIVCGLSGLC, respectively, determined by Edman degradation and mass spectrometry. They are structurally related to nigrocins identified from skin secretions of the dark-spotted frog, Rana nigromaculata. The cDNA clones encoding the precursor of grahamins were screened and sequenced from the skin cDNA library of R. grahami. The amino sequences deduced from the cDNA sequences match well with the results from Edman degradation. As other antimicrobial peptides from Rana species, grahamins contain a C-terminal loop region delineated by an intra-disulfide bridge named Rana box. Based on structural comparison of grahamin with other known antimicrobial peptides, grahamins could be classified into the family of antimicrobial peptides containing a single intra-disulfide bridge. |
| 收录类别 | SCI |
| 资助信息 | This work was supported by the Chinese National Natural Science Foundation (30200044, 30570360), Yun- nan Natural Science Foundation (2005C0054M) and Jiangsu Natural Science Foundation (BK2005422). |
| 语种 | 英语 |
| 源URL | [http://159.226.149.26:8080/handle/152453/10882]  |
| 专题 | 昆明动物研究所_动物毒素室 昆明动物研究所_动物模型与人类重大疾病机理重点实验室 |
| 作者单位 | 1.Laboratories of Animal Toxicology, Center for Animal Models and Human Disease Mechanisms, Kunming Institute of Zoology, Chinese Academy of Sciences, 32 East Jiao Chang Road, Kunming, Yunnan 650223, China 2.College of Life Sciences, Nanjing Agricultural University, Nanjing, Jiangsu 210095, China 3.Graduate School of the Chinese Academy of Sciences, Beijing 100009, China 4.Department of Life Science & Technology, Changshu Institute of Technology, Changshu, Jiangsu 215500, China |
| 推荐引用方式 GB/T 7714 | Xu XQ,Li JX,Lu QM,et al. Two antimicrobial peptides from skin secretions of Rana grahami[J]. TOXICON,2006,47(4):459-464. |
| APA | Xu XQ.,Li JX.,Lu QM.,Lai R[*].,Han YP.,...&Liang JG.(2006).Two antimicrobial peptides from skin secretions of Rana grahami.TOXICON,47(4),459-464. |
| MLA | Xu XQ,et al."Two antimicrobial peptides from skin secretions of Rana grahami".TOXICON 47.4(2006):459-464. |
入库方式： OAI收割
来源：昆明动物研究所
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