Cloning of novel bombesin precursor cDNAs from skin of Bombina maxima
文献类型：期刊论文
| 作者 | Shen JH1,2; Liu SB1; Zhang YX1; Jin Y1; Lee WH1; Zhang Y[*]1 |
| 刊名 | REGULATORY PEPTIDES
 |
| 出版日期 | 2005 |
| 卷号 | 132期号:1-3页码:102-106 |
| 关键词 | Amphibian Bombesin Bombestatin Bombina maxima cDNA Sequence |
| ISSN号 | 0167-0115 |
| 通讯作者 | zhangy@mail.kiz.ac.cn |
| 英文摘要 | Amphibian skin is a rich resource of bioactive peptides like proline-rich bombesin from frog Bombina maxima. A novel cDNA clone encoding a precursor protein that comprises proline-rich bombesin and a novel peptide, designated as bombestatin, was isolated from a skin cDNA library of B. maxima. The predicted primary structure of the novel peptide is WEVLLNVALIRLELLSCRSSKDQDQKESCGMHSW, in which two cysteines form a disulfide bond. A BLAST search of databases did not detect sequences with significant similarity. Bombestatin possesses dose-dependent contractile activity on rat stomach strips. The differences between cDNAs encoding PR-bombesin plus bombestatin and PR-bombesin alone are due to fragment insertions located in 3'-coding region and 3'-untranslational region, respectively. |
| 收录类别 | SCI |
| 资助信息 | This work was supported by ‘‘Western Light Project’’ from The Chinese Academy of Sciences to Dr. W-H. Lee and Dr. Y. Zhang; and grants from National Natural Science Foundation (30170195, 30470380) and Yunnan Science and Technology Commission (2003C0066M). |
| 原文出处 | 2005132102.pdf |
| 语种 | 英语 |
| 公开日期 | 2010-08-24 |
| 源URL | [http://159.226.149.42:8088/handle/152453/2663]  |
| 专题 | 昆明动物研究所_动物活性蛋白多肽组学 |
| 作者单位 | 1.Department of Animal Toxinology, Kunming Institute of Zoology, The Chinese Academy of Sciences, 32 East Jiao Chang Road, Kunming, Yunnan 650223, China 2.The First Affiliated Hospital of Kunming Medical College, Kunming, Yunnan 650032, China |
| 推荐引用方式 GB/T 7714 | Shen JH,Liu SB,Zhang YX,et al. Cloning of novel bombesin precursor cDNAs from skin of Bombina maxima[J]. REGULATORY PEPTIDES,2005,132(1-3):102-106. |
| APA | Shen JH,Liu SB,Zhang YX,Jin Y,Lee WH,&Zhang Y[*].(2005).Cloning of novel bombesin precursor cDNAs from skin of Bombina maxima.REGULATORY PEPTIDES,132(1-3),102-106. |
| MLA | Shen JH,et al."Cloning of novel bombesin precursor cDNAs from skin of Bombina maxima".REGULATORY PEPTIDES 132.1-3(2005):102-106. |
入库方式： OAI收割
来源：昆明动物研究所
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