Maximins S, a novel group of antimicrobial peptides from toad Bombina maxima
文献类型：期刊论文
| 作者 | Wang T1,2; Zhang J1,2; Shen JH1,3; Jin Y1; Lee WH1; Zhang Y[*]1 |
| 刊名 | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
 |
| 出版日期 | 2005 |
| 卷号 | 327期号:3页码:945-951 |
| 关键词 | Amphibian Antimicrobial peptide Antimycoplasma Bombina maxima cDNA sequence Maximin S peptide |
| ISSN号 | 0006-291X |
| 通讯作者 | zhangy@mail.kiz.ac.cn |
| 合作状况 | 其它 |
| 英文摘要 | Amphibian skin secretions are rich in antimicrobial peptides acting as important components of innate defense system against invading microorganisms. A novel type of peptide, designated as maximin S, was deduced by random sequencing of 793 clones from a constructed Bombina maxima skin cDNA library. The putative primary structures of maximin S peptides can be grouped into five species, in which maximin S1 has 14 amino acid residues and the rest of maximin S peptides (S2-S5) all have 18 amino acid residues. Unlike most of the amphibian antimicrobial peptides so far identified, the newly characterized four maximin S precursors are composed of maximin S1 and different combinations of tandem repeated maximin S2-S5 linked by internal peptides. Except maximin S1, the predicted secondary structures of maximin S2-S5 show a similar amphipathic alpha-helical structure. MALDI-TOF mass spectrometry analysis of partially isolated skin secretions of the toad indicates that most of the deduced maximin S peptides are expressed. Two deduced maximin S peptides (S1, S4) were synthesized and their antimicrobial activities were tested. Maximin S4 only had an antibiotic activity against mycoplasma and had no antibacterial or antifungal activity toward tested strains. Maximin S1 had no activity under the same conditions. |
| 收录类别 | SCI |
| 资助信息 | This work was supported by the grants of ‘‘Western Light’’ projects from The Chinese Academy of Sciences to Y. Zhang and W.H. Lee; and grants from National Natural Science Foundation (30170195, 30470380), and Yunnan Science and Technology Commission (2001C0061M, 2001C0062M, and 2003C0066M). |
| 原文出处 | 2005327945.pdf |
| 语种 | 英语 |
| 公开日期 | 2010-08-24 |
| 源URL | [http://159.226.149.42:8088/handle/152453/2683]  |
| 专题 | 昆明动物研究所_动物活性蛋白多肽组学 |
| 作者单位 | 1.Department of Animal Toxinology, Kunming Institute of Zoology, The Chinese Academy of Sciences, Kunming, Yunnan 650223, China 2.Graduate School of The Chinese Academy of Sciences, Beijing 100039, China 3.The First Affiliated Hospital of Kunming Medical College, Kunming, Yunnan 650032, China |
| 推荐引用方式 GB/T 7714 | Wang T,Zhang J,Shen JH,et al. Maximins S, a novel group of antimicrobial peptides from toad Bombina maxima[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2005,327(3):945-951. |
| APA | Wang T,Zhang J,Shen JH,Jin Y,Lee WH,&Zhang Y[*].(2005).Maximins S, a novel group of antimicrobial peptides from toad Bombina maxima.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,327(3),945-951. |
| MLA | Wang T,et al."Maximins S, a novel group of antimicrobial peptides from toad Bombina maxima".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 327.3(2005):945-951. |
入库方式： OAI收割
来源：昆明动物研究所
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