Activation of protease-activated receptor (PAR) 1 by frog trefoil factor (TFF) 2 and PAR4 by human TFF2.
文献类型：期刊论文
| 作者 | Zhang Y1,2,3; Yu GY1,2,3; Wang YJ1,2,3; Xiang Y1,2,3; Gao Q1,2,3; Jiang P1,2,3; Zhang JT1,2,3; Lee WH1,2; Zhang Y[*]1,2 |
| 刊名 | CELLULAR AND MOLECULAR LIFE SCIENCES
 |
| 出版日期 | 2011 |
| 卷号 | 68期号:22页码:3771-3780 |
| 关键词 | Trefoil factor Protease-activated receptor Epithelial cells Cell migration Mucosal healing Platelet activation |
| 通讯作者 | zhangy@mail.kiz.ac.cn |
| 合作状况 | 其它 |
| 英文摘要 | Trefoil factors (TFFs) promote epithelial cell migration to reseal superficial wounds after mucosal injury, but their receptors and the molecular mechanisms underlying this process are poorly understood. In this study, we showed that frog TFF2 activates protease-activated receptor (PAR) 1 to induce human platelet aggregation. Based on this result, we further tested the involvement of PARs in human TFF2 (hTFF2)-promoted mucosal healing. hTFF2-stimulated migration of epithelial HT-29 cells was largely inhibited by PAR4 depletion with small interfering RNAs but not by PAR1 or PAR2 depletion. The PAR4-negative epithelial cell lines AGS and LoVo were highly responsive to hTFF2 as assessed by phosphorylation of ERK1/2 and cell migration upon PAR4 expression. Our findings suggest that hTFF2 promotes cell migration via PAR4. These findings will be helpful in further investigations into the functions and molecular mechanisms of TFFs and PARs in physiology and disease. |
| 收录类别 | SCI |
| 资助信息 | This work was supported by grants from the National Basic Research Program of China (973 Program, 2010CB529800), the Chinese National Natural Science Foundation (30630014, 30570359, and 30870304), and the Chinese Academy of Sciences ‘‘Key Research Direction’’ (KSCX2-YW-R-088). |
| 语种 | 英语 |
| 公开日期 | 2013-04-09 |
| 源URL | [http://159.226.149.42:8088/handle/152453/7329]  |
| 专题 | 昆明动物研究所_动物活性蛋白多肽组学 昆明动物研究所_动物模型与人类重大疾病机理重点实验室 |
| 作者单位 | 1.Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Kunming, Yunnan, China 2.Kunming Institute of Zoology, The Chinese Academy of Sciences, 32 East Jiaochang Road, Kunming, Yunnan 650223, China 3.Graduate School of the Chinese Academy of Sciences, Beijing 100049, China |
| 推荐引用方式 GB/T 7714 | Zhang Y,Yu GY,Wang YJ,et al. Activation of protease-activated receptor (PAR) 1 by frog trefoil factor (TFF) 2 and PAR4 by human TFF2.[J]. CELLULAR AND MOLECULAR LIFE SCIENCES,2011,68(22):3771-3780. |
| APA | Zhang Y.,Yu GY.,Wang YJ.,Xiang Y.,Gao Q.,...&Zhang Y[*].(2011).Activation of protease-activated receptor (PAR) 1 by frog trefoil factor (TFF) 2 and PAR4 by human TFF2..CELLULAR AND MOLECULAR LIFE SCIENCES,68(22),3771-3780. |
| MLA | Zhang Y,et al."Activation of protease-activated receptor (PAR) 1 by frog trefoil factor (TFF) 2 and PAR4 by human TFF2.".CELLULAR AND MOLECULAR LIFE SCIENCES 68.22(2011):3771-3780. |
入库方式： OAI收割
来源：昆明动物研究所
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