Aberrant expression of trefoil factor 3 is associated with colorectal carcinoma metastasis
文献类型：期刊论文
| 作者 | Huang YG1,2; Li YF3; Wang LP4; Zhang Y[*]1,2 |
| 刊名 | JOURNAL OF CANCER RESEARCH AND THERAPEUTICS
 |
| 出版日期 | 2013 |
| 卷号 | 9期号:3页码:376-380 |
| 关键词 | Trefoil factor 3 colorectal carcinoma cancer metastasis |
| 通讯作者 | zhangy@mail.kiz.ac.cn |
| 合作状况 | 其它 |
| 英文摘要 | Background: Recent evidence has indicated that the trefoil factor family possesses pivotal roles in the progression of human cancer. Aberrant expression of trefoil factor 3 (TFF3) has been reported to correlate with an aggressive tumor phenotype. However, the clinical importance of TFF3 expression in colorectal carcinomas (CRCs) has rarely been addressed. Purpose: To investigate the putative role of TFF3 in colorectal carcinogenesis and progress, and to clarify whether TFF3 could be a serum marker for CRCs. Materials and Methods: Fifty-six CRCs were sequenced for TFF3 mutations; subsets of the primary tumors were subjected to real-time quantitative reverse transcription polymerase chain reaction (RT-PCR) and immunohistochemistry analyses and serum TFF3 was detected by enzyme-linked immunosorbent assay (ELISA) for patients with CRCs. Results: No variants were detected in the code area of TFF3; TFF3 mRNA is increased in CRCs but not up to statistic significance when compared with paired normal colonic mucosa; TFF3 staining by immunohistochemistry in primary CRCs showed that increased expression of TFF3 is associated with lymph node metastases(LNM), and no significant differences were found with respect to patients sex, cancer cell differentiation and stage. Serum TFF3 is significantly elevated in patients with CRCs, especially CRCs with LNM. Conclusion: The results indicate that TFF3 point mutations seem to be a rare event in colorectal carcinogenesis; TFF3 expression may play a role in promoting lymph node metastases of CRCs and serum TFF3 may be a potential useful marker for patients with CRCs and their metastases. |
| 收录类别 | SCI |
| 资助信息 | This work was supported by grants from National Basic Research Program of China (973 Program, 2010CB529800), the Chinese National Natural Science Foundation (U1132601 and 31270835) and CAS grant KJZD-EW-L03 to Yun Zhang. |
| 语种 | 英语 |
| WOS记录号 | WOS:000325724000008 |
| 公开日期 | 2013-11-18 |
| 源URL | [http://159.226.149.42:8088/handle/152453/7705]  |
| 专题 | 昆明动物研究所_动物活性蛋白多肽组学 昆明动物研究所_动物模型与人类重大疾病机理重点实验室 |
| 作者单位 | 1.Tumor institue of Yunnan Province, The 3 rd Affiliated Hospital of kunming Medical Universit 2.The Graduate School of the Chinese Academy of Sciences, Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology 3.Colorectal Cancer Research Centre, the Tumor Hospital of Yunnan Province 4.Department of Pathology, Yan-an Hospital of Kunming, P R China |
| 推荐引用方式 GB/T 7714 | Huang YG,Li YF,Wang LP,et al. Aberrant expression of trefoil factor 3 is associated with colorectal carcinoma metastasis[J]. JOURNAL OF CANCER RESEARCH AND THERAPEUTICS,2013,9(3):376-380. |
| APA | Huang YG,Li YF,Wang LP,&Zhang Y[*].(2013).Aberrant expression of trefoil factor 3 is associated with colorectal carcinoma metastasis.JOURNAL OF CANCER RESEARCH AND THERAPEUTICS,9(3),376-380. |
| MLA | Huang YG,et al."Aberrant expression of trefoil factor 3 is associated with colorectal carcinoma metastasis".JOURNAL OF CANCER RESEARCH AND THERAPEUTICS 9.3(2013):376-380. |
入库方式： OAI收割
来源：昆明动物研究所
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