Circulating Serum Trefoil Factor 3 (TFF3) Is Dramatically Increased in Chronic Kidney Disease
文献类型：期刊论文
| 作者 | Du TY1,2,3; Luo HM4; Qin HC5; Wang F3; Wang Q6; Xiang Y1; Zhang Y[*]1 |
| 刊名 | PLOS ONE
 |
| 出版日期 | 2013 |
| 卷号 | 8期号:11页码:e80271 |
| 通讯作者 | zhangy@mail.kiz.ac.cn |
| 合作状况 | 其它 |
| 英文摘要 | Objectives: Trefoil factor 3 (TFF3) is a small peptide that plays an important role in mucosal protection, cell proliferation, and cell migration. The aberrant expression of TFF3 is correlated with gastrointestinal inflammation, solid tumors, and other clinical diseases. The objective of this study was to identify the distribution characteristics of serum TFF3 in common clinical diseases. Materials and Methods: A large prospective randomized study of 1,072 Chinese patients was performed using an enzyme-linked immunosorbent assay (ELISA) to examine the serum TFF3 concentrations in patients with different diseases. A matched case-control study was conducted on patients with chronic kidney disease (CKD) stages 1-5. Immunohistochemistry (IHC) was performed using renal tissues to determine the relationship between the severity of CKD and the serum and urine concentrations of TFF3 peptides. Results: The mean serum concentrations of TFF3 in patients with CKD, metastatic and secondary carcinoma (MC) and acute gastroenteritis (AG) (200.9 ng/ml, 95.7 ng/ml and 71.7 ng/ml, respectively) were significantly higher than those in patients with other common clinical diseases. A positive correlation tendency was observed between the serum TFF3 concentrations and the severity of CKD. The mean serum TFF3 values for CKD stages 1-5 were 23.6 ng/ml, 29.9 ng/ml, 54.9 ng/ml, 85.0 ng/ml and 176.6 ng/ml, respectively. The same trend was observed in the urine TFF3 concentrations and the CKD stages. The creatinine(Cr)-corrected concentrations of TFF3 in urine were 367.1 ng/mg.Cr, 910.6 ng/mg.Cr, 1,149.0 ng/mg.Cr, 1,610.0 ng/mg.Cr and 3,475.0 ng/mg.Cr for CKD stages 1-5, respectively. IHC revealed that TFF3 expression was concentrated in tubular epithelial cells. Conclusions: The influence of kidney injuries must be fully considered when performing clinical TFF3 research. Further studies on TFF3 in CKD will contribute to our understanding of its pathological roles and mechanisms in other diseases. |
| 收录类别 | SCI |
| 资助信息 | This work was supported by grants from the National Natural Science Foundation of China (NSFC-Yunnan joint funding U1132601, 31270835)JŒthe National Basic Research Program of China (973 Program, 2010CB529800), and the key research program of the Chinese Academy of Sciences (KJZD-EW-L03). |
| 语种 | 英语 |
| WOS记录号 | WOS:000327543500032 |
| 公开日期 | 2013-12-30 |
| 源URL | [http://159.226.149.42:8088/handle/152453/7754]  |
| 专题 | 昆明动物研究所_动物活性蛋白多肽组学 昆明动物研究所_动物模型与人类重大疾病机理重点实验室 |
| 作者单位 | 1.Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, The Chinese Academy of Sciences, Kunming, Yunnan Province, China 2.University of the Chinese Academy of Sciences, Beijing, China 3.Department of Clinical Laboratory Medicine, the First People’s Hospital of Yunnan Province, Kunming, Yunnan Province, China 4.Department of Nephrology, The First People’s Hospital of Yunnan Province, Kunming, Yunnan Province, China 5.Department of Gastroenterology, The First People’s Hospital of Yunnan Province, Kunming, Yunnan Province, China 6.Department of Gynecology, The First People’s Hospital of Yunnan Province,Kunming, Yunnan Province, China |
| 推荐引用方式 GB/T 7714 | Du TY,Luo HM,Qin HC,et al. Circulating Serum Trefoil Factor 3 (TFF3) Is Dramatically Increased in Chronic Kidney Disease[J]. PLOS ONE,2013,8(11):e80271. |
| APA | Du TY.,Luo HM.,Qin HC.,Wang F.,Wang Q.,...&Zhang Y[*].(2013).Circulating Serum Trefoil Factor 3 (TFF3) Is Dramatically Increased in Chronic Kidney Disease.PLOS ONE,8(11),e80271. |
| MLA | Du TY,et al."Circulating Serum Trefoil Factor 3 (TFF3) Is Dramatically Increased in Chronic Kidney Disease".PLOS ONE 8.11(2013):e80271. |
入库方式： OAI收割
来源：昆明动物研究所
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