Down-regulation of Protease-activated Receptor 4 in Lung Adenocarcinoma is Associated with a More Aggressive Phenotype
文献类型：期刊论文
| 作者 | Jiang P1,2,3; Yu GY1,4; Zhang Y[*]1; Xiang Y1; Hua HR3; Bian L5; Wang CY2,5; Lee WH1; Zhang Y[*]1 |
| 刊名 | ASIAN PACIFIC JOURNAL OF CANCER PREVENTION
 |
| 出版日期 | 2013 |
| 卷号 | 14期号:6页码:3793-3798 |
| 关键词 | PAR4 down-regulation tumor suppressor lung cancer adenocarcinoma |
| 通讯作者 | zhyong@mail.kiz.ac.cn ; zhangy@mail.kiz.ac.cn |
| 合作状况 | 其它 |
| 英文摘要 | The role of protease-activated receptors (PARs) in lung tumors is controversial. Although PAR4 is preferentially expressed in human lung tissues, its possible significance in lung cancer has not been defined. The studies reported herein used a combination of clinical observations and molecular methods. Surgically resected lung adenocarcinomas and associated adjacent normal lung tissues were collected and BEAS-2B and NCI-H157 cell lines were grown in tissue culture. PAR4 expression was evaluated by RT-PCR, RT-qPCR, Western blotting and immunohistochemistry analysis. The results showed that PAR4 mRNA expression was generally decreased in lung adenocarcinoma tissues as compared with matched noncancerous tissues (67.7%) and was associated with poor differentiation (p=0.017) and metastasis (p=0.04). Western blotting and immunohistochemical analysis also showed that PAR4 protein levels were mostly decreased in lung adenocarcinoma tissues (61.3%), and were also associated with poor differentiation (p=0.035) and clinical stage (p=0.027). Moreover, PAR4 expression was decreased in NCI-H157 cells as compared with BEAS-2B cells. In conclusion, PAR4 expression is significantly decreased in lung adenocarcinoma, and down-regulation of PAR4 is associated with a more clinically aggressive phenotype. PAR4 may acts as a tumor suppressor in lung adenocarcinoma. |
| 收录类别 | SCI |
| 资助信息 | This research is supported by grants from the Chinese National Natural Science Foundation (31270835, 31201720, 81160302), the Chinese Academy of Sciences the “Western Light Project” (Y102291081). |
| 语种 | 英语 |
| WOS记录号 | WOS:000331517700069 |
| 公开日期 | 2014-03-24 |
| 源URL | [http://159.226.149.42:8088/handle/152453/7826]  |
| 专题 | 昆明动物研究所_动物活性蛋白多肽组学 昆明动物研究所_动物模型与人类重大疾病机理重点实验室 |
| 作者单位 | 1.Key Laboratory of Animal Models and Human Disease Mechanisms, Kunming Institute of Zoology, Chinese Academy of Sciences, 2.University of Chinese Academy of Sciences, Beijing, China 3.Department of Pathology and Pathophysiology,the First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan 4.Department of Biochemistry, Kunming Medical University,the First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan 5.Department of Pathology, the First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan |
| 推荐引用方式 GB/T 7714 | Jiang P,Yu GY,Zhang Y[*],et al. Down-regulation of Protease-activated Receptor 4 in Lung Adenocarcinoma is Associated with a More Aggressive Phenotype[J]. ASIAN PACIFIC JOURNAL OF CANCER PREVENTION,2013,14(6):3793-3798. |
| APA | Jiang P.,Yu GY.,Zhang Y[*].,Xiang Y.,Hua HR.,...&Zhang Y[*].(2013).Down-regulation of Protease-activated Receptor 4 in Lung Adenocarcinoma is Associated with a More Aggressive Phenotype.ASIAN PACIFIC JOURNAL OF CANCER PREVENTION,14(6),3793-3798. |
| MLA | Jiang P,et al."Down-regulation of Protease-activated Receptor 4 in Lung Adenocarcinoma is Associated with a More Aggressive Phenotype".ASIAN PACIFIC JOURNAL OF CANCER PREVENTION 14.6(2013):3793-3798. |
入库方式： OAI收割
来源：昆明动物研究所
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