Bm-TFF2, a toad trefoil factor, promotes cell migration, survival and wound healing
文献类型：期刊论文
| 作者 | Zhang Y1,2; Yu GY1,2,3; Lee WH1; Zhang Y[*]1; Xiang Y1,2; Wu JB1; Jiang P1,2 |
| 刊名 | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
 |
| 出版日期 | 2010 |
| 卷号 | 398期号:3页码:559-564 |
| 关键词 | Amphibian Skin Trefoil factor Cell migration Wound healing Anti-apoptosis |
| 通讯作者 | zhangy@mail.kiz.ac.cn |
| 英文摘要 | Toad skin is naked and continually confronted by various injurious factors. Constant skin renewal and repairs occur frequently. However, the mechanisms of the renewal and repair have not clearly elucidated. In our previous work, a trefoil factor (TFF), Bm-TFF2, has been purified from the Bombina maxima skin and characterized as a platelet agonist. The mRNA of TFFs in toad skin was up-regulated greatly during the metamorphosis, indicating a pivotal role of TFFs in amphibian skin. Here, we presented the effects of Bm-TFF2 on the cell migration, apoptosis and proliferation. Bm-TFF2 bound to epithelial cells and showed strong cell motility activity. At the concentrations of 1-100 nM, Bm-TFF2-induced migration of human epithelial AGS and HT-29 cells, and rat intestinal epithelial IEC-6 cell lines. The in vitro wound healing assay also verified the activity of Bm-TFF2. Bm-TFF2 could also inhibit cell apoptosis induced by ceramide and sodium butyrate. The cell migration-promoting activity was abolished by MEK1 inhibitors, U0126 and PD98059, suggesting that ERK1/2 activation is crucial for Bm-TFF2 to stimulate cell migration. Taken together, Bm-TFF2 promoted wound healing by stimulating cell migration via MAPK pathway and preventing cell apoptosis. The potent biological activity of Bm-TFF2 makes it a useful molecular tool for further studies of structure-function relationship of the related human TFFs. |
| 收录类别 | SCI |
| 语种 | 英语 |
| 源URL | [http://159.226.149.26:8080/handle/152453/9606]  |
| 专题 | 昆明动物研究所_动物活性蛋白多肽组学 昆明动物研究所_动物模型与人类重大疾病机理重点实验室 |
| 作者单位 | 1.Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan 650223, China 2.Graduate School of Chinese Academy of Sciences, Beijing 100049, China 3.Department of Biochemistry, Kunming Medical College, Kunming, Yunnan 650032, China |
| 推荐引用方式 GB/T 7714 | Zhang Y,Yu GY,Lee WH,et al. Bm-TFF2, a toad trefoil factor, promotes cell migration, survival and wound healing[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2010,398(3):559-564. |
| APA | Zhang Y.,Yu GY.,Lee WH.,Zhang Y[*].,Xiang Y.,...&Jiang P.(2010).Bm-TFF2, a toad trefoil factor, promotes cell migration, survival and wound healing.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,398(3),559-564. |
| MLA | Zhang Y,et al."Bm-TFF2, a toad trefoil factor, promotes cell migration, survival and wound healing".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 398.3(2010):559-564. |
入库方式： OAI收割
来源：昆明动物研究所
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