Mammary gland stem cells and their application in breast cancer
文献类型：期刊论文
| 作者 | Yang X1,2; Wang H[*]1; Jiao BW[*]1 |
| 刊名 | Oncotarget
 |
| 出版日期 | 2016 |
| 卷号 | X期号:X页码:XX-XX |
| 关键词 | BCSCs MaSCs breast cancer stem cells mammary gland stem cells therapeutic perspectives |
| 通讯作者 | jiaobaowei@mail.kiz.ac.cn ; wanghui1@mail.kiz.ac.cn |
| 合作状况 | 其它 |
| 英文摘要 | The mammary gland is an organ comprising two primary lineages, specifically the inner luminal and the outer myoepithelial cell layers. Mammary gland stem cells (MaSCs) are highly dynamic and self-renewing, and can give rise to these mammary gland lineages. The lineages are responsible for gland generation during puberty as well as expansion during pregnancy. In recent years, researchers have focused on understanding how MaSCs are regulated during mammary gland development and transformation of breast cancer. Here, we summarize the identification of MaSCs, and how they are regulated by the signaling transduction pathways, mammary gland microenvironment, and non-coding RNAs (ncRNAs). Moreover, we debate the evidence for their serving as the origin of breast cancer, and discuss the therapeutic perspectives of targeting breast cancer stem cells (BCSCs). In conclusion, a better understanding of the key regulators of MaSCs is crucial for the clinical treatment of breast cancer. |
| 收录类别 | SCI |
| 资助信息 | This study was supported by the National Key Research and Development Program of China (No. 2016YFA0100903), Strategic Priority Research Program of the Chinese Academy of Sciences (No. XDB13030400), National Science Foundation of China (No. 31371502), and CAS “Light of West China” Program to H.W. |
| 语种 | 英语 |
| 源URL | [http://159.226.149.26:8080/handle/152453/10615]  |
| 专题 | 昆明动物研究所_发育的印迹调控与进化学 昆明动物研究所_遗传资源与进化国家重点实验室 |
| 作者单位 | 1.State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, China 2.University of Chinese Academy of Sciences, Beijing, China |
| 推荐引用方式 GB/T 7714 | Yang X,Wang H[*],Jiao BW[*]. Mammary gland stem cells and their application in breast cancer[J]. Oncotarget,2016,X(X):XX-XX. |
| APA | Yang X,Wang H[*],&Jiao BW[*].(2016).Mammary gland stem cells and their application in breast cancer.Oncotarget,X(X),XX-XX. |
| MLA | Yang X,et al."Mammary gland stem cells and their application in breast cancer".Oncotarget X.X(2016):XX-XX. |
入库方式： OAI收割
来源：昆明动物研究所
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