NEAT1 is Required for Survival of Breast Cancer Cells Through FUS and miR-548
文献类型：期刊论文
| 作者 | Hao K1,2; Zhao LM1,2; Yang Q1,2; Su XS4; Peng LT[*]5; Jiao BW[*]1,2; Feng X1,3; Xu HB1,2; Zou L1,2 |
| 刊名 | Gen Regulation and Systems Biology
 |
| 出版日期 | 2016 |
| 卷号 | 10期号:Suppl 1页码:11-17 |
| 关键词 | FUS NEAT1 cell apoptosis lncRNA miR-548ar-3p |
| 通讯作者 | jiaobaowei@mail.kiz.ac.cnor |
| 英文摘要 | Increasing evidence shows that long noncoding RNAs (lncRNAs) have important roles in the regulation of multiple cellular processes, including cell division, cell growth, and apoptosis, as well as cancer metastasis and neurological disease progression; however, the mechanism of how lncRNAs regulate these processes is not well established. In this study, we demonstrated that downregulating the expression of the lncRNA nuclear paraspeckle assembly transcript 1 (NEAT1) in breast cancer cells inhibited cell growth and induced cell apoptosis. In addition, the RNA-binding protein fused in sarcoma/translocated in liposarcoma (FUS/TLS) physically interacted with NEAT1, and reducing the expression of FUS/TLS also induced cell apoptosis. Multiple miRNAs were identified as regulators of NEAT1, but only overexpression of miR-548ar was able to decrease NEAT1 expression and promote apoptosis. These results indicate a novel interaction between NEAT1, miR-548ar-3p, and FUS and their role in the regulation of breast cancer cell apoptosis. |
| 收录类别 | SCI |
| 资助信息 | This study was supported by grants from the Strategic Priority Research Program of the Chinese academy of Sciences (no. XdB13030400) and the national Science Foundation of China (no. 31371502). |
| 源URL | [http://159.226.149.26:8080/handle/152453/9791]  |
| 专题 | 昆明动物研究所_发育的印迹调控与进化学 昆明动物研究所_遗传资源与进化国家重点实验室 |
| 作者单位 | 1.State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China 2.Kunming College of Life Science, University of Chinese Academy of Sciences, Kunming, China 3.Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, China 4.Biomedical Research Center, the First Hospital of Kunming, Kunming, China 5.Department of Biochemistry and Molecular Pharmacology, RNA Therapeutic Institute, University of Massachusetts Medical School, Worcester, MA, USA |
| 推荐引用方式 GB/T 7714 | Hao K,Zhao LM,Yang Q,et al. NEAT1 is Required for Survival of Breast Cancer Cells Through FUS and miR-548[J]. Gen Regulation and Systems Biology,2016,10(Suppl 1):11-17. |
| APA | Hao K.,Zhao LM.,Yang Q.,Su XS.,Peng LT[*].,...&Zou L.(2016).NEAT1 is Required for Survival of Breast Cancer Cells Through FUS and miR-548.Gen Regulation and Systems Biology,10(Suppl 1),11-17. |
| MLA | Hao K,et al."NEAT1 is Required for Survival of Breast Cancer Cells Through FUS and miR-548".Gen Regulation and Systems Biology 10.Suppl 1(2016):11-17. |
入库方式： OAI收割
来源：昆明动物研究所
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