Xenopus RCOR2 (REST corepressor 2) interacts with ZMYND8, which is involved in neural differentiation
文献类型：期刊论文
| 作者 | Zeng WL1,2; Kong QH1; Li CC1; Mao BY[*]1 |
| 刊名 | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
 |
| 出版日期 | 2010 |
| 卷号 | 394期号:4页码:1024-1029 |
| 关键词 | Xenopus RCOR2 ZMYND8 REST Neural differentiation |
| ISSN号 | 0006-291X |
| 通讯作者 | mao@mail.kiz.ac.cn |
| 合作状况 | 其它 |
| 英文摘要 | Regulation of neuronal gene expression is critical to nervous system development. REST (RE1-silencing transcription factor) regulates neuronal gene expression through interacting with a group of corepressor proteins including REST corepressors (RCOR). Here we show that Xenopus RCOR2 is predominantly expressed in the developing nervous system. Through a yeast two-hybrid screen, we isolated Xenopus ZMYND8 (Zinc finger and MYND domain containing 8) as an XRCOR2 interacting factor. XRCOR2 and XZMYND8 bind each other in co-immunoprecipitation assays and both of them can function as transcriptional repressors. XZMYND8 is co-expressed with XRCOR2 in the nervous system and overexpression of XZMYND8 inhibits neural differentiation in Xenopus embryos. These data reveal a RCOR2/ZMYND8 complex which might be involved in the regulation of neural differentiation. |
| 收录类别 | SCI |
| 资助信息 | This work was sup- ported by grants from the Key State Research Program from the Ministry of Science and Technology of China (2006CB943902 and 2007CB947201), the Innovation Project of Chinese Academy of Sci- ences (KSCX2-YW-R-090) and the National Natural Science Foun- dation of China (305303800). |
| 语种 | 英语 |
| 公开日期 | 2010-08-24 |
| 源URL | [http://159.226.149.42:8088/handle/152453/3169]  |
| 专题 | 昆明动物研究所_发育生物学 昆明动物研究所_遗传资源与进化国家重点实验室 |
| 作者单位 | 1.CAS-Max Planck Junior Scientist Group on Developmental Biology, State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, 32 Jiaochang East Road, Kunming 650223, China 2.Graduate University of Chinese Academy of Sciences, Beijing 100049, China |
| 推荐引用方式 GB/T 7714 | Zeng WL,Kong QH,Li CC,et al. Xenopus RCOR2 (REST corepressor 2) interacts with ZMYND8, which is involved in neural differentiation[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2010,394(4):1024-1029. |
| APA | Zeng WL,Kong QH,Li CC,&Mao BY[*].(2010).Xenopus RCOR2 (REST corepressor 2) interacts with ZMYND8, which is involved in neural differentiation.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,394(4),1024-1029. |
| MLA | Zeng WL,et al."Xenopus RCOR2 (REST corepressor 2) interacts with ZMYND8, which is involved in neural differentiation".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 394.4(2010):1024-1029. |
入库方式： OAI收割
来源：昆明动物研究所
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