Evolution of vertebrate central nervous system is accompanied by novel expression changes of duplicate genes
文献类型：期刊论文
| 作者 | Chen Y1,2; Ding Y1,2; Zhang ZM1,2; Wang W1; Chen JY3; Ueno NT4; Mao BY[*]1 |
| 刊名 | JOURNAL OF GENETICS AND GENOMICS
 |
| 出版日期 | 2011 |
| 卷号 | 38期号:12页码:577-584 |
| 关键词 | Central nervous system evolution Gene duplication Expression pattern Amphioxus Xenopus |
| 通讯作者 | mao@mail.kiz.ac.cn |
| 合作状况 | 其它 |
| 英文摘要 | The evolution of the central nervous system (CNS) is one of the most striking changes during the transition from invertebrates to vertebrates. As a major source of genetic novelties, gene duplication might play an important role in the functional innovation of vertebrate CNS. In this study, we focused on a group of CNS-biased genes that duplicated during early vertebrate evolution. We investigated the tempo-spatial expression patterns of 33 duplicate gene families and their orthologs during the embryonic development of the vertebrate Xenopus laevis and the cephalochordate Brachiostoma belcheri. Almost all the identified duplicate genes are differentially expressed in the CNS in Xenopus embryos, and more than 50% and 30% duplicate genes are expressed in the telencephalon and mid-hindbrain boundary, respectively, which are mostly considered as two innovations in the vertebrate CNS. Interestingly, more than 50% of the amphioxus orthologs do not show apparent expression in the CNS in amphioxus embryos as detected by in situ hybridization, indicating that some of the vertebrate CNS-biased duplicate genes might arise from non-CNS genes in invertebrates. Our data accentuate the functional contribution of gene duplication in the CNS evolution of vertebrate and uncover an invertebrate non-CNS history for some vertebrate CNS-biased duplicate genes. |
| 收录类别 | SCI |
| 资助信息 | This work was supported by the grants from the Innovation Project of Chinese Academy of Sciences (No. KSCX2-YW-R- 090) and the Key State Research Program from the Ministry of Science and Technology of China (No. 2007CB947201). |
| 语种 | 英语 |
| 公开日期 | 2012-03-16 |
| 源URL | [http://159.226.149.42:8088/handle/353002/6863]  |
| 专题 | 昆明动物研究所_发育生物学 昆明动物研究所_遗传资源与进化国家重点实验室 昆明动物研究所_基因起源组 |
| 作者单位 | 1.State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Jiaochang East Road 32, Kunming 650223, China 2.Graduate University of Chinese Academy of Sciences, Beijing 100049, China 3.School of Life Sciences, Nanjing University, Hankou Road, Nanjing, Jiangsu 210093, China 4.Division of Morphogenesis, National Institute for Basic Biology, Nishigonaka 38, Myodaiji, Okazaki, Aichi 444-8585, Japan |
| 推荐引用方式 GB/T 7714 | Chen Y,Ding Y,Zhang ZM,et al. Evolution of vertebrate central nervous system is accompanied by novel expression changes of duplicate genes[J]. JOURNAL OF GENETICS AND GENOMICS,2011,38(12):577-584. |
| APA | Chen Y.,Ding Y.,Zhang ZM.,Wang W.,Chen JY.,...&Mao BY[*].(2011).Evolution of vertebrate central nervous system is accompanied by novel expression changes of duplicate genes.JOURNAL OF GENETICS AND GENOMICS,38(12),577-584. |
| MLA | Chen Y,et al."Evolution of vertebrate central nervous system is accompanied by novel expression changes of duplicate genes".JOURNAL OF GENETICS AND GENOMICS 38.12(2011):577-584. |
入库方式： OAI收割
来源：昆明动物研究所
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